Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern

Summary: We compared the functional properties of spike (S) glycoproteins from the original SARS-CoV-2 strain (D614) (Wuhan, China), the globally dominant D614G strain, and emerging geographic variants: B.1.1.7 (United Kingdom), B.1.351 (South Africa), P.1 (Brazil), and B.1.1.248 (Brazil/Japan). Com...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qian Wang, Manoj S. Nair, Saumya Anang, Shijian Zhang, Hanh Nguyen, Yaoxing Huang, Lihong Liu, David D. Ho, Joseph G. Sodroski
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Virology Science Q
Acceso en línea:	https://doaj.org/article/817f7383f9c644aeb47fad695c9369d4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:817f7383f9c644aeb47fad695c9369d4
record_format	dspace
spelling	oai:doaj.org-article:817f7383f9c644aeb47fad695c9369d42021-11-20T05:11:08ZFunctional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern2589-004210.1016/j.isci.2021.103393https://doaj.org/article/817f7383f9c644aeb47fad695c9369d42021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S258900422101364Xhttps://doaj.org/toc/2589-0042Summary: We compared the functional properties of spike (S) glycoproteins from the original SARS-CoV-2 strain (D614) (Wuhan, China), the globally dominant D614G strain, and emerging geographic variants: B.1.1.7 (United Kingdom), B.1.351 (South Africa), P.1 (Brazil), and B.1.1.248 (Brazil/Japan). Compared with D614G, the emerging variants exhibited an increased affinity for the receptor, ACE2, and increased ability to infect cells with low ACE2 levels. All variants lost infectivity similarly at room temperature and 37°C; however, in the cold, B.1.1.7 was more stable, and P.1 and B.1.1.248 were less stable. Shedding of the S1 glycoprotein from the S contributed to virus inactivation in the cold. B.1.351, P.1, and B.1.1.248 were neutralized by convalescent and vaccinee sera less efficiently than the other variants. S glycoprotein properties such as requirements for ACE2 levels on the target cell, functional stability in the cold, and resistance to host neutralizing antibodies potentially contribute to the outgrowth of emerging SARS-CoV-2 variants.Qian WangManoj S. NairSaumya AnangShijian ZhangHanh NguyenYaoxing HuangLihong LiuDavid D. HoJoseph G. SodroskiElsevierarticleVirologyScienceQENiScience, Vol 24, Iss 11, Pp 103393- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Virology Science Q
spellingShingle	Virology Science Q Qian Wang Manoj S. Nair Saumya Anang Shijian Zhang Hanh Nguyen Yaoxing Huang Lihong Liu David D. Ho Joseph G. Sodroski Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern
description	Summary: We compared the functional properties of spike (S) glycoproteins from the original SARS-CoV-2 strain (D614) (Wuhan, China), the globally dominant D614G strain, and emerging geographic variants: B.1.1.7 (United Kingdom), B.1.351 (South Africa), P.1 (Brazil), and B.1.1.248 (Brazil/Japan). Compared with D614G, the emerging variants exhibited an increased affinity for the receptor, ACE2, and increased ability to infect cells with low ACE2 levels. All variants lost infectivity similarly at room temperature and 37°C; however, in the cold, B.1.1.7 was more stable, and P.1 and B.1.1.248 were less stable. Shedding of the S1 glycoprotein from the S contributed to virus inactivation in the cold. B.1.351, P.1, and B.1.1.248 were neutralized by convalescent and vaccinee sera less efficiently than the other variants. S glycoprotein properties such as requirements for ACE2 levels on the target cell, functional stability in the cold, and resistance to host neutralizing antibodies potentially contribute to the outgrowth of emerging SARS-CoV-2 variants.
format	article
author	Qian Wang Manoj S. Nair Saumya Anang Shijian Zhang Hanh Nguyen Yaoxing Huang Lihong Liu David D. Ho Joseph G. Sodroski
author_facet	Qian Wang Manoj S. Nair Saumya Anang Shijian Zhang Hanh Nguyen Yaoxing Huang Lihong Liu David D. Ho Joseph G. Sodroski
author_sort	Qian Wang
title	Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern
title_short	Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern
title_full	Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern
title_fullStr	Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern
title_full_unstemmed	Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern
title_sort	functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/817f7383f9c644aeb47fad695c9369d4
work_keys_str_mv	AT qianwang functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern AT manojsnair functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern AT saumyaanang functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern AT shijianzhang functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern AT hanhnguyen functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern AT yaoxinghuang functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern AT lihongliu functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern AT daviddho functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern AT josephgsodroski functionaldifferencesamongthespikeglycoproteinsofmultipleemergingsevereacuterespiratorysyndromecoronavirus2variantsofconcern
_version_	1718419551252643840

Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern

Ejemplares similares