Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

APOBEC3G (A3G) belongs to the DNA/RNA cytosine deaminase family that plays important roles in innate immunity against HIV and internal retroelements. Here the authors report the structures of two full-length A3G variants that provides insight into domain organization, multimerization, RNA binding, a...

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Autores principales: Hanjing Yang, Fumiaki Ito, Aaron D. Wolfe, Shuxing Li, Nazanin Mohammadzadeh, Robin P. Love, Maocai Yan, Brett Zirkle, Amit Gaba, Linda Chelico, Xiaojiang S. Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/81810bdeadd84813b61a8392fef16fb6
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