The emerging role of nimotuzumab in the treatment of non-small cell lung cancer
William Boland1, Gwyn Bebb2,31Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada; 2Tom Baker Cancer Centre, Calgary, Alberta, Canada; 3University of Calgary, Calgary, Alberta, CanadaAbstract: Current non-small cell lung cancer (NSCLC) chemotherapy and radiotherapy re...
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Dove Medical Press
2010
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oai:doaj.org-article:8182e1b313a0478e8099dcde220e23cc2021-12-02T03:20:17ZThe emerging role of nimotuzumab in the treatment of non-small cell lung cancer1177-54751177-5491https://doaj.org/article/8182e1b313a0478e8099dcde220e23cc2010-11-01T00:00:00Zhttp://www.dovepress.com/the-emerging-role-of-nimotuzumab-in-the-treatment-of-non-small-cell-lu-a5617https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491William Boland1, Gwyn Bebb2,31Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada; 2Tom Baker Cancer Centre, Calgary, Alberta, Canada; 3University of Calgary, Calgary, Alberta, CanadaAbstract: Current non-small cell lung cancer (NSCLC) chemotherapy and radiotherapy regimens, although showing definite survival benefit, still leave patients with a disappointing 15% 5-year overall survival rate. Because of the need to improve traditional outcomes, research has focused on identifying specific tumorigenic pathways that may serve as therapeutic targets. The most successful strategies to date are those aimed at the epidermal growth factor receptor (EGFR), which is found to be upregulated in 40%–80% of NSCLC. Several tyrosine kinase inhibitors and monoclonal antibodies (mAbs) have been developed that inhibit the EGFR receptor and have demonstrated clinical benefit in trials as single agents and in combination regimens. Here we discuss one such agent, the mAb nimotuzumab, the background of its development, its clinical experience in NSCLC thus far, and the rationale for expanding its use to other NSCLC treatment settings.Keywords: non-small cell lung cancer, chemotherapy, radiotherapy, overall survival, EGFR William BolandGwyn BebbDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 289-298 (2010) |
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DOAJ |
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EN |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 William Boland Gwyn Bebb The emerging role of nimotuzumab in the treatment of non-small cell lung cancer |
| description |
William Boland1, Gwyn Bebb2,31Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada; 2Tom Baker Cancer Centre, Calgary, Alberta, Canada; 3University of Calgary, Calgary, Alberta, CanadaAbstract: Current non-small cell lung cancer (NSCLC) chemotherapy and radiotherapy regimens, although showing definite survival benefit, still leave patients with a disappointing 15% 5-year overall survival rate. Because of the need to improve traditional outcomes, research has focused on identifying specific tumorigenic pathways that may serve as therapeutic targets. The most successful strategies to date are those aimed at the epidermal growth factor receptor (EGFR), which is found to be upregulated in 40%–80% of NSCLC. Several tyrosine kinase inhibitors and monoclonal antibodies (mAbs) have been developed that inhibit the EGFR receptor and have demonstrated clinical benefit in trials as single agents and in combination regimens. Here we discuss one such agent, the mAb nimotuzumab, the background of its development, its clinical experience in NSCLC thus far, and the rationale for expanding its use to other NSCLC treatment settings.Keywords: non-small cell lung cancer, chemotherapy, radiotherapy, overall survival, EGFR |
| format |
article |
| author |
William Boland Gwyn Bebb |
| author_facet |
William Boland Gwyn Bebb |
| author_sort |
William Boland |
| title |
The emerging role of nimotuzumab in the treatment of non-small cell lung cancer |
| title_short |
The emerging role of nimotuzumab in the treatment of non-small cell lung cancer |
| title_full |
The emerging role of nimotuzumab in the treatment of non-small cell lung cancer |
| title_fullStr |
The emerging role of nimotuzumab in the treatment of non-small cell lung cancer |
| title_full_unstemmed |
The emerging role of nimotuzumab in the treatment of non-small cell lung cancer |
| title_sort |
emerging role of nimotuzumab in the treatment of non-small cell lung cancer |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/8182e1b313a0478e8099dcde220e23cc |
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1718401803926634496 |