CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.

Recovery of sensory and motor functions following traumatic spinal cord injury (SCI) is dependent on injury severity. Here we identified 49 proteins from cerebrospinal fluid (CSF) of SCI patients, eight of which were differentially abundant among two severity groups of SCI. It was observed that the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohor Biplab Sengupta, Mahashweta Basu, Sourav Iswarari, Kiran Kumar Mukhopadhyay, Krishna Pada Sardar, Biplab Acharyya, Pradeep K Mohanty, Debashis Mukhopadhyay
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81868b80ecf14dafb9edd473b477b37f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:81868b80ecf14dafb9edd473b477b37f
record_format	dspace
spelling	oai:doaj.org-article:81868b80ecf14dafb9edd473b477b37f2021-11-25T05:55:10ZCSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.1932-620310.1371/journal.pone.0110885https://doaj.org/article/81868b80ecf14dafb9edd473b477b37f2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110885https://doaj.org/toc/1932-6203Recovery of sensory and motor functions following traumatic spinal cord injury (SCI) is dependent on injury severity. Here we identified 49 proteins from cerebrospinal fluid (CSF) of SCI patients, eight of which were differentially abundant among two severity groups of SCI. It was observed that the abundance profiles of these proteins change over a time period of days to months post SCI. Statistical analysis revealed that these proteins take part in several molecular pathways including DNA repair, protein phosphorylation, tRNA transcription, iron transport, mRNA metabolism, immune response and lipid and ATP catabolism. These pathways reflect a set of mechanisms that the system may adopt to cope up with the assault depending on the injury severity, thus leading to observed physiological responses. Apart from putting forward a picture of the molecular scenario at the injury site in a human study, this finding further delineates consequent pathways and molecules that may be altered by external intervention to restrict neural degeneration.Mohor Biplab SenguptaMahashweta BasuSourav IswarariKiran Kumar MukhopadhyayKrishna Pada SardarBiplab AcharyyaPradeep K MohantyDebashis MukhopadhyayPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110885 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohor Biplab Sengupta Mahashweta Basu Sourav Iswarari Kiran Kumar Mukhopadhyay Krishna Pada Sardar Biplab Acharyya Pradeep K Mohanty Debashis Mukhopadhyay CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.
description	Recovery of sensory and motor functions following traumatic spinal cord injury (SCI) is dependent on injury severity. Here we identified 49 proteins from cerebrospinal fluid (CSF) of SCI patients, eight of which were differentially abundant among two severity groups of SCI. It was observed that the abundance profiles of these proteins change over a time period of days to months post SCI. Statistical analysis revealed that these proteins take part in several molecular pathways including DNA repair, protein phosphorylation, tRNA transcription, iron transport, mRNA metabolism, immune response and lipid and ATP catabolism. These pathways reflect a set of mechanisms that the system may adopt to cope up with the assault depending on the injury severity, thus leading to observed physiological responses. Apart from putting forward a picture of the molecular scenario at the injury site in a human study, this finding further delineates consequent pathways and molecules that may be altered by external intervention to restrict neural degeneration.
format	article
author	Mohor Biplab Sengupta Mahashweta Basu Sourav Iswarari Kiran Kumar Mukhopadhyay Krishna Pada Sardar Biplab Acharyya Pradeep K Mohanty Debashis Mukhopadhyay
author_facet	Mohor Biplab Sengupta Mahashweta Basu Sourav Iswarari Kiran Kumar Mukhopadhyay Krishna Pada Sardar Biplab Acharyya Pradeep K Mohanty Debashis Mukhopadhyay
author_sort	Mohor Biplab Sengupta
title	CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.
title_short	CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.
title_full	CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.
title_fullStr	CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.
title_full_unstemmed	CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.
title_sort	csf proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/81868b80ecf14dafb9edd473b477b37f
work_keys_str_mv	AT mohorbiplabsengupta csfproteomicsofsecondaryphasespinalcordinjuryinhumansubjectsperturbedmolecularpathwayspostinjury AT mahashwetabasu csfproteomicsofsecondaryphasespinalcordinjuryinhumansubjectsperturbedmolecularpathwayspostinjury AT souraviswarari csfproteomicsofsecondaryphasespinalcordinjuryinhumansubjectsperturbedmolecularpathwayspostinjury AT kirankumarmukhopadhyay csfproteomicsofsecondaryphasespinalcordinjuryinhumansubjectsperturbedmolecularpathwayspostinjury AT krishnapadasardar csfproteomicsofsecondaryphasespinalcordinjuryinhumansubjectsperturbedmolecularpathwayspostinjury AT biplabacharyya csfproteomicsofsecondaryphasespinalcordinjuryinhumansubjectsperturbedmolecularpathwayspostinjury AT pradeepkmohanty csfproteomicsofsecondaryphasespinalcordinjuryinhumansubjectsperturbedmolecularpathwayspostinjury AT debashismukhopadhyay csfproteomicsofsecondaryphasespinalcordinjuryinhumansubjectsperturbedmolecularpathwayspostinjury
_version_	1718414411181326336

CSF proteomics of secondary phase spinal cord injury in human subjects: perturbed molecular pathways post injury.

Ejemplares similares