Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival o...

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Autores principales:	Mayuko Uehara, Martina M. McGrath, Shunsuke Ohori, Zhabiz Solhjou, Naima Banouni, Sujit Routray, Catherine Evans, Jonathan P. DiNitto, Abdallah Elkhal, Laurence A. Turka, Terry B. Strom, Stefan G. Tullius, David G. Winkler, Jamil Azzi, Reza Abdi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/818831b33b2247b79607d6e3430cab97
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spelling	oai:doaj.org-article:818831b33b2247b79607d6e3430cab972021-12-02T15:37:01ZRegulation of T cell alloimmunity by PI3Kγ and PI3Kδ10.1038/s41467-017-00982-x2041-1723https://doaj.org/article/818831b33b2247b79607d6e3430cab972017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00982-xhttps://doaj.org/toc/2041-1723Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival outcomes post CTLA4-Ig treatment.Mayuko UeharaMartina M. McGrathShunsuke OhoriZhabiz SolhjouNaima BanouniSujit RoutrayCatherine EvansJonathan P. DiNittoAbdallah ElkhalLaurence A. TurkaTerry B. StromStefan G. TulliusDavid G. WinklerJamil AzziReza AbdiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mayuko Uehara Martina M. McGrath Shunsuke Ohori Zhabiz Solhjou Naima Banouni Sujit Routray Catherine Evans Jonathan P. DiNitto Abdallah Elkhal Laurence A. Turka Terry B. Strom Stefan G. Tullius David G. Winkler Jamil Azzi Reza Abdi Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
description	Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival outcomes post CTLA4-Ig treatment.
format	article
author	Mayuko Uehara Martina M. McGrath Shunsuke Ohori Zhabiz Solhjou Naima Banouni Sujit Routray Catherine Evans Jonathan P. DiNitto Abdallah Elkhal Laurence A. Turka Terry B. Strom Stefan G. Tullius David G. Winkler Jamil Azzi Reza Abdi
author_facet	Mayuko Uehara Martina M. McGrath Shunsuke Ohori Zhabiz Solhjou Naima Banouni Sujit Routray Catherine Evans Jonathan P. DiNitto Abdallah Elkhal Laurence A. Turka Terry B. Strom Stefan G. Tullius David G. Winkler Jamil Azzi Reza Abdi
author_sort	Mayuko Uehara
title	Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
title_short	Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
title_full	Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
title_fullStr	Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
title_full_unstemmed	Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
title_sort	regulation of t cell alloimmunity by pi3kγ and pi3kδ
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/818831b33b2247b79607d6e3430cab97
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Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

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