Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival o...

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Autores principales: Mayuko Uehara, Martina M. McGrath, Shunsuke Ohori, Zhabiz Solhjou, Naima Banouni, Sujit Routray, Catherine Evans, Jonathan P. DiNitto, Abdallah Elkhal, Laurence A. Turka, Terry B. Strom, Stefan G. Tullius, David G. Winkler, Jamil Azzi, Reza Abdi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/818831b33b2247b79607d6e3430cab97
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