Nucleases as molecular targets for cancer diagnosis
Abstract Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain a...
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BMC
2021
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oai:doaj.org-article:81886691815e489c95595163db30eb7e2021-11-28T12:08:15ZNucleases as molecular targets for cancer diagnosis10.1186/s40364-021-00342-42050-7771https://doaj.org/article/81886691815e489c95595163db30eb7e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40364-021-00342-4https://doaj.org/toc/2050-7771Abstract Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The implications of nucleases are key for biological functions, their presence in different cellular counterparts and catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers. However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. This review discusses nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, it highlights the potential of harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates.Alien BalianFrank J. HernandezBMCarticleNucleaseNuclease activitycancer biomarkerscancer diagnosticsNucleic acid probes, novel diagnosticsTherapeutics. PharmacologyRM1-950ENBiomarker Research, Vol 9, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Nuclease Nuclease activity cancer biomarkers cancer diagnostics Nucleic acid probes, novel diagnostics Therapeutics. Pharmacology RM1-950 |
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Nuclease Nuclease activity cancer biomarkers cancer diagnostics Nucleic acid probes, novel diagnostics Therapeutics. Pharmacology RM1-950 Alien Balian Frank J. Hernandez Nucleases as molecular targets for cancer diagnosis |
| description |
Abstract Early cancer diagnosis is a crucial element to improved treatment options and survival. Great research efforts have been made in the search for better performing cancer diagnostic biomarkers. However, the quest continues as novel biomarkers with high accuracy for an early diagnosis remain an unmet clinical need. Nucleases, which are enzymes capable of cleaving nucleic acids, have been long considered as potential cancer biomarkers. The implications of nucleases are key for biological functions, their presence in different cellular counterparts and catalytic activity led the enthusiasm towards investigating the role of nucleases as promising cancer biomarkers. However, the most essential feature of these proteins, which is their enzymatic activity, has not been fully exploited. This review discusses nucleases interrogated as cancer biomarkers, providing a glimpse of their physiological roles. Moreover, it highlights the potential of harnessing the enzymatic activity of cancer-associated nucleases as a novel diagnostic biomarker using nucleic acid probes as substrates. |
| format |
article |
| author |
Alien Balian Frank J. Hernandez |
| author_facet |
Alien Balian Frank J. Hernandez |
| author_sort |
Alien Balian |
| title |
Nucleases as molecular targets for cancer diagnosis |
| title_short |
Nucleases as molecular targets for cancer diagnosis |
| title_full |
Nucleases as molecular targets for cancer diagnosis |
| title_fullStr |
Nucleases as molecular targets for cancer diagnosis |
| title_full_unstemmed |
Nucleases as molecular targets for cancer diagnosis |
| title_sort |
nucleases as molecular targets for cancer diagnosis |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/81886691815e489c95595163db30eb7e |
| work_keys_str_mv |
AT alienbalian nucleasesasmoleculartargetsforcancerdiagnosis AT frankjhernandez nucleasesasmoleculartargetsforcancerdiagnosis |
| _version_ |
1718408207885402112 |