Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes

We assessed associations between infant diet (e.g., breastfeeding and introduction to solid foods) and DNA methylation in infancy and childhood. We measured DNA methylation in peripheral blood collected in infancy (9–15 months of age) in 243 children; and in a subset of 50 children, we also measured...

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Autores principales:	Elizabeth Walker-Short, Teresa Buckner, Timothy Vigers, Patrick Carry, Lauren A. Vanderlinden, Fran Dong, Randi K. Johnson, Ivana V. Yang, Katerina Kechris, Marian Rewers, Jill M. Norris
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	methylation breastfeeding infant diet Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/818c28b3aa5c42888db46f6d2b03890f
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spelling	oai:doaj.org-article:818c28b3aa5c42888db46f6d2b03890f2021-11-25T18:36:26ZEpigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes10.3390/nu131140572072-6643https://doaj.org/article/818c28b3aa5c42888db46f6d2b03890f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4057https://doaj.org/toc/2072-6643We assessed associations between infant diet (e.g., breastfeeding and introduction to solid foods) and DNA methylation in infancy and childhood. We measured DNA methylation in peripheral blood collected in infancy (9–15 months of age) in 243 children; and in a subset of 50 children, we also measured methylation in childhood (6–9 years of age) to examine persistence, and at birth (in cord blood) to examine temporality. We performed multivariable linear regression of infant diet on the outcome of methylation using epigenome-wide and candidate site approaches. We identified six novel CpG sites associated with breastfeeding duration using an EWAS approach. One differentially methylated site presented directionally consistent associations with breastfeeding (cg00574958, <i>CPT1A</i>) in infancy and childhood but not at birth. Two differentially methylated sites in infancy (cg19693031, <i>TXNIP</i>; cg23307264, <i>KHSRP</i>) were associated with breastfeeding and were not present at birth; however, these associations did not persist into childhood. Associations between infant diet and methylation in infancy at three sites (cg22369607, <i>AP001525.1</i>; cg2409200, <i>TBCD</i>; cg27173510, <i>PGBD5</i>) were also present at birth, suggesting the influence of exposures other than infant diet. Infant diet exposures are associated with persistent methylation differences in <i>CPT1A</i>, which may be one mechanism behind infant diet’s long-term health effects.Elizabeth Walker-ShortTeresa BucknerTimothy VigersPatrick CarryLauren A. VanderlindenFran DongRandi K. JohnsonIvana V. YangKaterina KechrisMarian RewersJill M. NorrisMDPI AGarticlemethylationbreastfeedinginfant dietNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4057, p 4057 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	methylation breastfeeding infant diet Nutrition. Foods and food supply TX341-641
spellingShingle	methylation breastfeeding infant diet Nutrition. Foods and food supply TX341-641 Elizabeth Walker-Short Teresa Buckner Timothy Vigers Patrick Carry Lauren A. Vanderlinden Fran Dong Randi K. Johnson Ivana V. Yang Katerina Kechris Marian Rewers Jill M. Norris Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes
description	We assessed associations between infant diet (e.g., breastfeeding and introduction to solid foods) and DNA methylation in infancy and childhood. We measured DNA methylation in peripheral blood collected in infancy (9–15 months of age) in 243 children; and in a subset of 50 children, we also measured methylation in childhood (6–9 years of age) to examine persistence, and at birth (in cord blood) to examine temporality. We performed multivariable linear regression of infant diet on the outcome of methylation using epigenome-wide and candidate site approaches. We identified six novel CpG sites associated with breastfeeding duration using an EWAS approach. One differentially methylated site presented directionally consistent associations with breastfeeding (cg00574958, <i>CPT1A</i>) in infancy and childhood but not at birth. Two differentially methylated sites in infancy (cg19693031, <i>TXNIP</i>; cg23307264, <i>KHSRP</i>) were associated with breastfeeding and were not present at birth; however, these associations did not persist into childhood. Associations between infant diet and methylation in infancy at three sites (cg22369607, <i>AP001525.1</i>; cg2409200, <i>TBCD</i>; cg27173510, <i>PGBD5</i>) were also present at birth, suggesting the influence of exposures other than infant diet. Infant diet exposures are associated with persistent methylation differences in <i>CPT1A</i>, which may be one mechanism behind infant diet’s long-term health effects.
format	article
author	Elizabeth Walker-Short Teresa Buckner Timothy Vigers Patrick Carry Lauren A. Vanderlinden Fran Dong Randi K. Johnson Ivana V. Yang Katerina Kechris Marian Rewers Jill M. Norris
author_facet	Elizabeth Walker-Short Teresa Buckner Timothy Vigers Patrick Carry Lauren A. Vanderlinden Fran Dong Randi K. Johnson Ivana V. Yang Katerina Kechris Marian Rewers Jill M. Norris
author_sort	Elizabeth Walker-Short
title	Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes
title_short	Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes
title_full	Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes
title_fullStr	Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes
title_full_unstemmed	Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes
title_sort	epigenome-wide association study of infant feeding and dna methylation in infancy and childhood in a population at increased risk for type 1 diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/818c28b3aa5c42888db46f6d2b03890f
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Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes

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