Inflammation and bone mineral density: A Mendelian randomization study

Abstract Osteoporosis is a common age-related disorder leading to an increase in osteoporotic fractures and resulting in significant suffering and disability. Inflammation may contribute to osteoporosis, as it does to many other chronic diseases. We examined whether inflammation is etiologically rel...

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Autores principales:	Jian V. Huang, C. Mary Schooling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8191b0eceee34cd9a068ed126127a593
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spelling	oai:doaj.org-article:8191b0eceee34cd9a068ed126127a5932021-12-02T16:07:03ZInflammation and bone mineral density: A Mendelian randomization study10.1038/s41598-017-09080-w2045-2322https://doaj.org/article/8191b0eceee34cd9a068ed126127a5932017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09080-whttps://doaj.org/toc/2045-2322Abstract Osteoporosis is a common age-related disorder leading to an increase in osteoporotic fractures and resulting in significant suffering and disability. Inflammation may contribute to osteoporosis, as it does to many other chronic diseases. We examined whether inflammation is etiologically relevant to osteoporosis, assessed from bone mineral density (BMD), as a new potential target of intervention, or whether it is a symptom/biomarker of osteoporosis. We obtained genetic predictors of inflammatory markers from genome-wide association studies and applied them to a large genome wide association study of BMD. Using two-sample Mendelian randomization, we obtained unconfounded estimates of the effect of high-sensitivity C-reactive protein (hsCRP) on BMD at the forearm, femoral neck, and lumbar spine. After removing potentially pleiotropic single nucleotide polymorphisms (SNPs) possibly acting via obesity-related traits, hsCRP, based on 16 SNPs from genes including CRP, was not associated with BMD. A causal relation of hsCRP with lower BMD was not evident in this study.Jian V. HuangC. Mary SchoolingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian V. Huang C. Mary Schooling Inflammation and bone mineral density: A Mendelian randomization study
description	Abstract Osteoporosis is a common age-related disorder leading to an increase in osteoporotic fractures and resulting in significant suffering and disability. Inflammation may contribute to osteoporosis, as it does to many other chronic diseases. We examined whether inflammation is etiologically relevant to osteoporosis, assessed from bone mineral density (BMD), as a new potential target of intervention, or whether it is a symptom/biomarker of osteoporosis. We obtained genetic predictors of inflammatory markers from genome-wide association studies and applied them to a large genome wide association study of BMD. Using two-sample Mendelian randomization, we obtained unconfounded estimates of the effect of high-sensitivity C-reactive protein (hsCRP) on BMD at the forearm, femoral neck, and lumbar spine. After removing potentially pleiotropic single nucleotide polymorphisms (SNPs) possibly acting via obesity-related traits, hsCRP, based on 16 SNPs from genes including CRP, was not associated with BMD. A causal relation of hsCRP with lower BMD was not evident in this study.
format	article
author	Jian V. Huang C. Mary Schooling
author_facet	Jian V. Huang C. Mary Schooling
author_sort	Jian V. Huang
title	Inflammation and bone mineral density: A Mendelian randomization study
title_short	Inflammation and bone mineral density: A Mendelian randomization study
title_full	Inflammation and bone mineral density: A Mendelian randomization study
title_fullStr	Inflammation and bone mineral density: A Mendelian randomization study
title_full_unstemmed	Inflammation and bone mineral density: A Mendelian randomization study
title_sort	inflammation and bone mineral density: a mendelian randomization study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8191b0eceee34cd9a068ed126127a593
work_keys_str_mv	AT jianvhuang inflammationandbonemineraldensityamendelianrandomizationstudy AT cmaryschooling inflammationandbonemineraldensityamendelianrandomizationstudy
_version_	1718384786823708672

Inflammation and bone mineral density: A Mendelian randomization study

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