Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

The mechanisms promoting insulin resistance at the receptor level are poorly understood. Here, Choi et al. show that mitotic proteins and the SHP2-MAPK pathway regulate receptor endocytosis and insulin signaling feedback, identifying a potential role for SHP2 inhibitors to treat diabetes.

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Autores principales:	Eunhee Choi, Sotaro Kikuchi, Haishan Gao, Karolina Brodzik, Ibrahim Nassour, Adam Yopp, Amit G. Singal, Hao Zhu, Hongtao Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/819277c64772481c8648587394125c81
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spelling	oai:doaj.org-article:819277c64772481c8648587394125c812021-12-02T14:35:31ZMitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling10.1038/s41467-019-09318-32041-1723https://doaj.org/article/819277c64772481c8648587394125c812019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09318-3https://doaj.org/toc/2041-1723The mechanisms promoting insulin resistance at the receptor level are poorly understood. Here, Choi et al. show that mitotic proteins and the SHP2-MAPK pathway regulate receptor endocytosis and insulin signaling feedback, identifying a potential role for SHP2 inhibitors to treat diabetes.Eunhee ChoiSotaro KikuchiHaishan GaoKarolina BrodzikIbrahim NassourAdam YoppAmit G. SingalHao ZhuHongtao YuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eunhee Choi Sotaro Kikuchi Haishan Gao Karolina Brodzik Ibrahim Nassour Adam Yopp Amit G. Singal Hao Zhu Hongtao Yu Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
description	The mechanisms promoting insulin resistance at the receptor level are poorly understood. Here, Choi et al. show that mitotic proteins and the SHP2-MAPK pathway regulate receptor endocytosis and insulin signaling feedback, identifying a potential role for SHP2 inhibitors to treat diabetes.
format	article
author	Eunhee Choi Sotaro Kikuchi Haishan Gao Karolina Brodzik Ibrahim Nassour Adam Yopp Amit G. Singal Hao Zhu Hongtao Yu
author_facet	Eunhee Choi Sotaro Kikuchi Haishan Gao Karolina Brodzik Ibrahim Nassour Adam Yopp Amit G. Singal Hao Zhu Hongtao Yu
author_sort	Eunhee Choi
title	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_short	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_full	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_fullStr	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_full_unstemmed	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_sort	mitotic regulators and the shp2-mapk pathway promote ir endocytosis and feedback regulation of insulin signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/819277c64772481c8648587394125c81
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Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

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