Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells

Conventional T cell subsets are selected in the thymus by peptide bearing MHC expressed by cortical epithelial cells, in contrast cortical thymocytes express non-peptide bearing MHC molecules including CD1d and MR1 and select iNKT and MAIT cell populations respectively. Here, the authors generate a...

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Autores principales:	Hristo Georgiev, Changwei Peng, Matthew A. Huggins, Stephen C. Jameson, Kristin A. Hogquist
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81950d9bb43444afbba3babc90ee020b
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spelling	oai:doaj.org-article:81950d9bb43444afbba3babc90ee020b2021-12-02T15:51:06ZClassical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells10.1038/s41467-021-22589-z2041-1723https://doaj.org/article/81950d9bb43444afbba3babc90ee020b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22589-zhttps://doaj.org/toc/2041-1723Conventional T cell subsets are selected in the thymus by peptide bearing MHC expressed by cortical epithelial cells, in contrast cortical thymocytes express non-peptide bearing MHC molecules including CD1d and MR1 and select iNKT and MAIT cell populations respectively. Here, the authors generate a novel inducible MHC class-I trasnactivator murine system and suggest the absence of peptide-MHC on thymocytes is involved in the selection of non-peptide specific lymphocytes.Hristo GeorgievChangwei PengMatthew A. HugginsStephen C. JamesonKristin A. HogquistNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hristo Georgiev Changwei Peng Matthew A. Huggins Stephen C. Jameson Kristin A. Hogquist Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells
description	Conventional T cell subsets are selected in the thymus by peptide bearing MHC expressed by cortical epithelial cells, in contrast cortical thymocytes express non-peptide bearing MHC molecules including CD1d and MR1 and select iNKT and MAIT cell populations respectively. Here, the authors generate a novel inducible MHC class-I trasnactivator murine system and suggest the absence of peptide-MHC on thymocytes is involved in the selection of non-peptide specific lymphocytes.
format	article
author	Hristo Georgiev Changwei Peng Matthew A. Huggins Stephen C. Jameson Kristin A. Hogquist
author_facet	Hristo Georgiev Changwei Peng Matthew A. Huggins Stephen C. Jameson Kristin A. Hogquist
author_sort	Hristo Georgiev
title	Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells
title_short	Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells
title_full	Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells
title_fullStr	Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells
title_full_unstemmed	Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells
title_sort	classical mhc expression by dp thymocytes impairs the selection of non-classical mhc restricted innate-like t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81950d9bb43444afbba3babc90ee020b
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Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells

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