Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells

Conventional T cell subsets are selected in the thymus by peptide bearing MHC expressed by cortical epithelial cells, in contrast cortical thymocytes express non-peptide bearing MHC molecules including CD1d and MR1 and select iNKT and MAIT cell populations respectively. Here, the authors generate a...

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Auteurs principaux: Hristo Georgiev, Changwei Peng, Matthew A. Huggins, Stephen C. Jameson, Kristin A. Hogquist
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/81950d9bb43444afbba3babc90ee020b
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