Sulfonylureas and cardiovascular complications of type 2 diabetes mellitus

This article addresses possible mechanisms for development of cardiovascular events (CVE) in type 2 diabetes mellitus (T2DM) patients treated with sulfonylurea derivatives (SU). Several problems are highlighted in this review, including molecular aspects of pancreatic and extrapancreatic action of t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Lyudmila Viktorovna Nedosugova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	type 2 diabetes mellitus sulfonylureas sur katp channel ischemic preconditioning Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/819541cfb8404b78a7efb9920250ac0f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:819541cfb8404b78a7efb9920250ac0f
record_format	dspace
spelling	oai:doaj.org-article:819541cfb8404b78a7efb9920250ac0f2021-11-14T09:00:18ZSulfonylureas and cardiovascular complications of type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-3753https://doaj.org/article/819541cfb8404b78a7efb9920250ac0f2013-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3753https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378This article addresses possible mechanisms for development of cardiovascular events (CVE) in type 2 diabetes mellitus (T2DM) patients treated with sulfonylurea derivatives (SU). Several problems are highlighted in this review, including molecular aspects of pancreatic and extrapancreatic action of these drugs, their comparative potential to induce hypoglycemic events (as predictors of acute CVE) and impairment of ischemic preconditioning, as well as antiarrhythmic activity of certain SU agents. Finally, efficacy and cardiovascular safety of glimepiride in T2DM patients is substantiated based on a survey of current literature.Lyudmila Viktorovna NedosugovaEndocrinology Research Centrearticletype 2 diabetes mellitussulfonylureassurkatp channelischemic preconditioningNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 2, Pp 26-35 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus sulfonylureas sur katp channel ischemic preconditioning Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus sulfonylureas sur katp channel ischemic preconditioning Nutritional diseases. Deficiency diseases RC620-627 Lyudmila Viktorovna Nedosugova Sulfonylureas and cardiovascular complications of type 2 diabetes mellitus
description	This article addresses possible mechanisms for development of cardiovascular events (CVE) in type 2 diabetes mellitus (T2DM) patients treated with sulfonylurea derivatives (SU). Several problems are highlighted in this review, including molecular aspects of pancreatic and extrapancreatic action of these drugs, their comparative potential to induce hypoglycemic events (as predictors of acute CVE) and impairment of ischemic preconditioning, as well as antiarrhythmic activity of certain SU agents. Finally, efficacy and cardiovascular safety of glimepiride in T2DM patients is substantiated based on a survey of current literature.
format	article
author	Lyudmila Viktorovna Nedosugova
author_facet	Lyudmila Viktorovna Nedosugova
author_sort	Lyudmila Viktorovna Nedosugova
title	Sulfonylureas and cardiovascular complications of type 2 diabetes mellitus
title_short	Sulfonylureas and cardiovascular complications of type 2 diabetes mellitus
title_full	Sulfonylureas and cardiovascular complications of type 2 diabetes mellitus
title_fullStr	Sulfonylureas and cardiovascular complications of type 2 diabetes mellitus
title_full_unstemmed	Sulfonylureas and cardiovascular complications of type 2 diabetes mellitus
title_sort	sulfonylureas and cardiovascular complications of type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/819541cfb8404b78a7efb9920250ac0f
work_keys_str_mv	AT lyudmilaviktorovnanedosugova sulfonylureasandcardiovascularcomplicationsoftype2diabetesmellitus
_version_	1718429590074949632

Sulfonylureas and cardiovascular complications of type 2 diabetes mellitus

Ejemplares similares