Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis

Breast cancer is one of the most commonly diagnosed malignancies and the leading cause of cancer death in women worldwide. Although many factors associated with breast cancer have been identified, the definite etiology of breast cancer is still unclear. In addition, early diagnosis of breast cancer...

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Autores principales:	Wenwen Chen, Zhongyu Li, Pengwei Deng, Zhengnan Li, Yuhai Xu, Hongjing Li, Wentao Su, Jianhua Qin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	exosome miRNAs breast cancer diagnosis potential biomarkers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/81a16f94789444f69df00579fd8eee98
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id	oai:doaj.org-article:81a16f94789444f69df00579fd8eee98
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spelling	oai:doaj.org-article:81a16f94789444f69df00579fd8eee982021-11-25T17:22:04ZAdvances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis10.3390/diagnostics111121512075-4418https://doaj.org/article/81a16f94789444f69df00579fd8eee982021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2151https://doaj.org/toc/2075-4418Breast cancer is one of the most commonly diagnosed malignancies and the leading cause of cancer death in women worldwide. Although many factors associated with breast cancer have been identified, the definite etiology of breast cancer is still unclear. In addition, early diagnosis of breast cancer remains challenging. Exosomes are membrane-bound nanovesicles secreted by most types of cells and contain a series of biologically important molecules, such as lipids, proteins, and miRNAs, etc. Emerging evidence shows that exosomes can affect the status of cells by transmitting substances and messages among cells and are involved in various physiological and pathological processes. In breast cancer, exosomes play a significant role in breast tumorigenesis and progression through transfer miRNAs which can be potential biomarkers for early diagnosis of breast cancer. This review discusses the potential utility of exosomal miRNAs in breast cancer progression such as tumorigenesis, metastasis, immune regulation and drug resistance, and further in breast cancer diagnosis.Wenwen ChenZhongyu LiPengwei DengZhengnan LiYuhai XuHongjing LiWentao SuJianhua QinMDPI AGarticleexosomemiRNAsbreast cancerdiagnosispotential biomarkersMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2151, p 2151 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exosome miRNAs breast cancer diagnosis potential biomarkers Medicine (General) R5-920
spellingShingle	exosome miRNAs breast cancer diagnosis potential biomarkers Medicine (General) R5-920 Wenwen Chen Zhongyu Li Pengwei Deng Zhengnan Li Yuhai Xu Hongjing Li Wentao Su Jianhua Qin Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis
description	Breast cancer is one of the most commonly diagnosed malignancies and the leading cause of cancer death in women worldwide. Although many factors associated with breast cancer have been identified, the definite etiology of breast cancer is still unclear. In addition, early diagnosis of breast cancer remains challenging. Exosomes are membrane-bound nanovesicles secreted by most types of cells and contain a series of biologically important molecules, such as lipids, proteins, and miRNAs, etc. Emerging evidence shows that exosomes can affect the status of cells by transmitting substances and messages among cells and are involved in various physiological and pathological processes. In breast cancer, exosomes play a significant role in breast tumorigenesis and progression through transfer miRNAs which can be potential biomarkers for early diagnosis of breast cancer. This review discusses the potential utility of exosomal miRNAs in breast cancer progression such as tumorigenesis, metastasis, immune regulation and drug resistance, and further in breast cancer diagnosis.
format	article
author	Wenwen Chen Zhongyu Li Pengwei Deng Zhengnan Li Yuhai Xu Hongjing Li Wentao Su Jianhua Qin
author_facet	Wenwen Chen Zhongyu Li Pengwei Deng Zhengnan Li Yuhai Xu Hongjing Li Wentao Su Jianhua Qin
author_sort	Wenwen Chen
title	Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis
title_short	Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis
title_full	Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis
title_fullStr	Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis
title_full_unstemmed	Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis
title_sort	advances of exosomal mirnas in breast cancer progression and diagnosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/81a16f94789444f69df00579fd8eee98
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Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis

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