Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the binding of IL6 to its receptor IL6Rα.

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Detalles Bibliográficos
Autores principales: Mohammed Soutto, Zheng Chen, Ajaz A. Bhat, Lihong Wang, Shoumin Zhu, Ahmed Gomaa, Andreia Bates, Nadeem S. Bhat, Dunfa Peng, Abbes Belkhiri, M. Blanca Piazuelo, M. Kay Washington, Xi Chen Steven, Richard Peek, Wael El-Rifai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/81a301b3784f4121a5bbe07006272423
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Descripción
Sumario:Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the binding of IL6 to its receptor IL6Rα.

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