Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the binding of IL6 to its receptor IL6Rα.

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Autores principales: Mohammed Soutto, Zheng Chen, Ajaz A. Bhat, Lihong Wang, Shoumin Zhu, Ahmed Gomaa, Andreia Bates, Nadeem S. Bhat, Dunfa Peng, Abbes Belkhiri, M. Blanca Piazuelo, M. Kay Washington, Xi Chen Steven, Richard Peek, Wael El-Rifai
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/81a301b3784f4121a5bbe07006272423
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spelling oai:doaj.org-article:81a301b3784f4121a5bbe070062724232021-12-02T17:01:33ZActivation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia10.1038/s41467-019-11011-42041-1723https://doaj.org/article/81a301b3784f4121a5bbe070062724232019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11011-4https://doaj.org/toc/2041-1723Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the binding of IL6 to its receptor IL6Rα.Mohammed SouttoZheng ChenAjaz A. BhatLihong WangShoumin ZhuAhmed GomaaAndreia BatesNadeem S. BhatDunfa PengAbbes BelkhiriM. Blanca PiazueloM. Kay WashingtonXi Chen StevenRichard PeekWael El-RifaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mohammed Soutto
Zheng Chen
Ajaz A. Bhat
Lihong Wang
Shoumin Zhu
Ahmed Gomaa
Andreia Bates
Nadeem S. Bhat
Dunfa Peng
Abbes Belkhiri
M. Blanca Piazuelo
M. Kay Washington
Xi Chen Steven
Richard Peek
Wael El-Rifai
Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
description Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the binding of IL6 to its receptor IL6Rα.
format article
author Mohammed Soutto
Zheng Chen
Ajaz A. Bhat
Lihong Wang
Shoumin Zhu
Ahmed Gomaa
Andreia Bates
Nadeem S. Bhat
Dunfa Peng
Abbes Belkhiri
M. Blanca Piazuelo
M. Kay Washington
Xi Chen Steven
Richard Peek
Wael El-Rifai
author_facet Mohammed Soutto
Zheng Chen
Ajaz A. Bhat
Lihong Wang
Shoumin Zhu
Ahmed Gomaa
Andreia Bates
Nadeem S. Bhat
Dunfa Peng
Abbes Belkhiri
M. Blanca Piazuelo
M. Kay Washington
Xi Chen Steven
Richard Peek
Wael El-Rifai
author_sort Mohammed Soutto
title Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
title_short Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
title_full Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
title_fullStr Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
title_full_unstemmed Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia
title_sort activation of stat3 signaling is mediated by tff1 silencing in gastric neoplasia
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/81a301b3784f4121a5bbe07006272423
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