A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.

Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via preferential antidromic blockade of slow axons....

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Autores principales:	Míriam R García, Barak A Pearlmutter, Peter E Wellstead, Richard H Middleton
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81a720d7948442d5840914ee166d57fd
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spelling	oai:doaj.org-article:81a720d7948442d5840914ee166d57fd2021-11-18T08:55:13ZA slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.1932-620310.1371/journal.pone.0073456https://doaj.org/article/81a720d7948442d5840914ee166d57fd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24066049/?tool=EBIhttps://doaj.org/toc/1932-6203Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via preferential antidromic blockade of slow axons. The antidromic blockade is preferential because the pulses more rapidly clear fast axons, and the distribution of axonal diameters, and therefore velocities, in the involved tracts, is sufficiently long-tailed to make this effect quite significant. The preferential blockade of slow axons, combined with gain adaptation, results in a reduction of the mean delay in the motor control loop, which serves to stabilize the feedback system, thus ameliorating tremor. This theory, without any tuning, accounts for several previously perplexing phenomena, and makes a variety of novel predictions.Míriam R GarcíaBarak A PearlmutterPeter E WellsteadRichard H MiddletonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73456 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Míriam R García Barak A Pearlmutter Peter E Wellstead Richard H Middleton A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.
description	Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via preferential antidromic blockade of slow axons. The antidromic blockade is preferential because the pulses more rapidly clear fast axons, and the distribution of axonal diameters, and therefore velocities, in the involved tracts, is sufficiently long-tailed to make this effect quite significant. The preferential blockade of slow axons, combined with gain adaptation, results in a reduction of the mean delay in the motor control loop, which serves to stabilize the feedback system, thus ameliorating tremor. This theory, without any tuning, accounts for several previously perplexing phenomena, and makes a variety of novel predictions.
format	article
author	Míriam R García Barak A Pearlmutter Peter E Wellstead Richard H Middleton
author_facet	Míriam R García Barak A Pearlmutter Peter E Wellstead Richard H Middleton
author_sort	Míriam R García
title	A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.
title_short	A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.
title_full	A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.
title_fullStr	A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.
title_full_unstemmed	A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.
title_sort	slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/81a720d7948442d5840914ee166d57fd
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A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.

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