The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies

Antechinus are a genus of mouse-like marsupials that exhibit a rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for the brown antechinus (Antechi...

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Autores principales:	Parice A. Brandies, Simon Tang, Robert S. P. Johnson, Carolyn J. Hogg, Katherine Belov
Formato:	article
Lenguaje:	EN
Publicado:	GigaScience Press 2020
Materias:	Electronic computers. Computer science QA75.5-76.95
Acceso en línea:	https://doaj.org/article/81a82d0479044e4aaf4eb1425dc3b1a9
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spelling	oai:doaj.org-article:81a82d0479044e4aaf4eb1425dc3b1a92021-12-02T15:00:33ZThe first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies10.46471/gigabyte.72709-4715https://doaj.org/article/81a82d0479044e4aaf4eb1425dc3b1a92020-11-01T00:00:00Zhttps://gigabytejournal.com/articles/7https://doaj.org/toc/2709-4715 Antechinus are a genus of mouse-like marsupials that exhibit a rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for the brown antechinus (Antechinus stuartii). The reference genome is 3.3 Gb in size with a scaffold N50 of 73Mb and 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds to chromosomes and identify 0.78 Mb of Y-chromosome scaffolds. Comparative genomics revealed interesting expansions in the NMRK2 gene and the protocadherin gamma family, which have previously been associated with aging and age-related dementias respectively. Transcriptome data displayed expression of common Alzheimer’s related genes in the antechinus brain and highlight the potential of utilising the antechinus as a future disease model. The valuable genomic resources provided herein will enable future research to explore the genetic basis of semelparity and age-related processes in the antechinus. Parice A. BrandiesSimon TangRobert S. P. JohnsonCarolyn J. HoggKatherine BelovGigaScience PressarticleElectronic computers. Computer scienceQA75.5-76.95ENGigaByte (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Electronic computers. Computer science QA75.5-76.95
spellingShingle	Electronic computers. Computer science QA75.5-76.95 Parice A. Brandies Simon Tang Robert S. P. Johnson Carolyn J. Hogg Katherine Belov The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
description	Antechinus are a genus of mouse-like marsupials that exhibit a rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for the brown antechinus (Antechinus stuartii). The reference genome is 3.3 Gb in size with a scaffold N50 of 73Mb and 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds to chromosomes and identify 0.78 Mb of Y-chromosome scaffolds. Comparative genomics revealed interesting expansions in the NMRK2 gene and the protocadherin gamma family, which have previously been associated with aging and age-related dementias respectively. Transcriptome data displayed expression of common Alzheimer’s related genes in the antechinus brain and highlight the potential of utilising the antechinus as a future disease model. The valuable genomic resources provided herein will enable future research to explore the genetic basis of semelparity and age-related processes in the antechinus.
format	article
author	Parice A. Brandies Simon Tang Robert S. P. Johnson Carolyn J. Hogg Katherine Belov
author_facet	Parice A. Brandies Simon Tang Robert S. P. Johnson Carolyn J. Hogg Katherine Belov
author_sort	Parice A. Brandies
title	The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
title_short	The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
title_full	The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
title_fullStr	The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
title_full_unstemmed	The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
title_sort	first antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies
publisher	GigaScience Press
publishDate	2020
url	https://doaj.org/article/81a82d0479044e4aaf4eb1425dc3b1a9
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The first Antechinus reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies

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