VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION

We realized, the definition, of polymorphic variants of genes of folate cycle (C677T, A1298C, A66G) in children with, essential hypertension, having the burdened, and not burdened, hereditary anamnesis of thrombosis. Frequency of the incidence of low functional allele polymorphisms C677T and. A1298C...

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Autores principales:	V. V. Dolgikh, S. E. Bolshakova, E. S. Philippov, M. V. Gomellya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	hypertension gene polymorphisms homocysteine hyperhomocysteinemia Science Q
Acceso en línea:	https://doaj.org/article/81aa044fcc1b4bd8910e54d2684ac327
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spelling	oai:doaj.org-article:81aa044fcc1b4bd8910e54d2684ac3272021-11-23T06:14:18ZVARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION2541-94202587-9596https://doaj.org/article/81aa044fcc1b4bd8910e54d2684ac3272012-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/809https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596We realized, the definition, of polymorphic variants of genes of folate cycle (C677T, A1298C, A66G) in children with, essential hypertension, having the burdened, and not burdened, hereditary anamnesis of thrombosis. Frequency of the incidence of low functional allele polymorphisms C677T and. A1298C didn't exceed, ubiquitous in the general population, and. in agreement with, those obtained, in other studies, with, an unfavorable genotype GG A66G gene was more frequent than in the population. In all groups of children studied, most often occurred in the carriage of any one of the polymorphic genes, but the combination, of two or even three adverse alleles also met with, relatively high, frequency. No statistically significant differences in the distribution, of genotypes between groups were found.V. V. DolgikhS. E. BolshakovaE. S. PhilippovM. V. GomellyaScientific Сentre for Family Health and Human Reproduction Problemsarticlehypertensiongene polymorphismshomocysteinehyperhomocysteinemiaScienceQRUActa Biomedica Scientifica, Vol 0, Iss 2(2), Pp 26-29 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	hypertension gene polymorphisms homocysteine hyperhomocysteinemia Science Q
spellingShingle	hypertension gene polymorphisms homocysteine hyperhomocysteinemia Science Q V. V. Dolgikh S. E. Bolshakova E. S. Philippov M. V. Gomellya VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION
description	We realized, the definition, of polymorphic variants of genes of folate cycle (C677T, A1298C, A66G) in children with, essential hypertension, having the burdened, and not burdened, hereditary anamnesis of thrombosis. Frequency of the incidence of low functional allele polymorphisms C677T and. A1298C didn't exceed, ubiquitous in the general population, and. in agreement with, those obtained, in other studies, with, an unfavorable genotype GG A66G gene was more frequent than in the population. In all groups of children studied, most often occurred in the carriage of any one of the polymorphic genes, but the combination, of two or even three adverse alleles also met with, relatively high, frequency. No statistically significant differences in the distribution, of genotypes between groups were found.
format	article
author	V. V. Dolgikh S. E. Bolshakova E. S. Philippov M. V. Gomellya
author_facet	V. V. Dolgikh S. E. Bolshakova E. S. Philippov M. V. Gomellya
author_sort	V. V. Dolgikh
title	VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION
title_short	VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION
title_full	VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION
title_fullStr	VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION
title_full_unstemmed	VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION
title_sort	variability of genes of folate cycle in children with essential arterial hypertension
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/81aa044fcc1b4bd8910e54d2684ac327
work_keys_str_mv	AT vvdolgikh variabilityofgenesoffolatecycleinchildrenwithessentialarterialhypertension AT sebolshakova variabilityofgenesoffolatecycleinchildrenwithessentialarterialhypertension AT esphilippov variabilityofgenesoffolatecycleinchildrenwithessentialarterialhypertension AT mvgomellya variabilityofgenesoffolatecycleinchildrenwithessentialarterialhypertension
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VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION

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