An Egg-Derived Sulfated <i>N</i> -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines
Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation patterns than viruses circulating among humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived glycan that is an an...
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American Society for Microbiology
2021
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oai:doaj.org-article:81abede94fff4444880ebd5e2daf346d2021-11-03T21:15:03Z An Egg-Derived Sulfated <i>N</i> -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines 2150-751110.1128/mBio.00838-21https://doaj.org/article/81abede94fff4444880ebd5e2daf346d2021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00838-21https://doaj.org/toc/2150-7511 Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation patterns than viruses circulating among humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived glycan that is an antigenic decoy, with egg-binding MAbs reacting with a sulfated NJenna J. GuthmillerHenry A. UtsetCarole HenryLei LiNai-Ying ZhengWeina SunMarcos Costa VieiraSeth ZostMin HuangScott E. HensleySarah CobeyPeter PalesePatrick C. WilsonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Jenna J. Guthmiller Henry A. Utset Carole Henry Lei Li Nai-Ying Zheng Weina Sun Marcos Costa Vieira Seth Zost Min Huang Scott E. Hensley Sarah Cobey Peter Palese Patrick C. Wilson An Egg-Derived Sulfated <i>N</i> -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines |
| description |
Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation patterns than viruses circulating among humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived glycan that is an antigenic decoy, with egg-binding MAbs reacting with a sulfated
N |
| format |
article |
| author |
Jenna J. Guthmiller Henry A. Utset Carole Henry Lei Li Nai-Ying Zheng Weina Sun Marcos Costa Vieira Seth Zost Min Huang Scott E. Hensley Sarah Cobey Peter Palese Patrick C. Wilson |
| author_facet |
Jenna J. Guthmiller Henry A. Utset Carole Henry Lei Li Nai-Ying Zheng Weina Sun Marcos Costa Vieira Seth Zost Min Huang Scott E. Hensley Sarah Cobey Peter Palese Patrick C. Wilson |
| author_sort |
Jenna J. Guthmiller |
| title |
An Egg-Derived Sulfated
<i>N</i>
-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines
|
| title_short |
An Egg-Derived Sulfated
<i>N</i>
-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines
|
| title_full |
An Egg-Derived Sulfated
<i>N</i>
-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines
|
| title_fullStr |
An Egg-Derived Sulfated
<i>N</i>
-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines
|
| title_full_unstemmed |
An Egg-Derived Sulfated
<i>N</i>
-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines
|
| title_sort |
egg-derived sulfated
<i>n</i>
-acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/81abede94fff4444880ebd5e2daf346d |
| work_keys_str_mv |
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