Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency

Abstract The nasal mucosa (NM) contains olfactory mucosa which contributes to the detection of odorant molecules and the transmission of olfactory information to the brain. To date, the lipid composition of the human NM has not been adequately characterized. Using gas chromatography, liquid chromato...

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Autores principales:	Spiro Khoury, Volker Gudziol, Stéphane Grégoire, Stéphanie Cabaret, Susanne Menzel, Lucy Martine, Esther Mézière, Vanessa Soubeyre, Thierry Thomas-Danguin, Xavier Grosmaitre, Lionel Bretillon, Olivier Berdeaux, Niyazi Acar, Thomas Hummel, Anne Marie Le Bon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81ac6e49487f4cfc9035cafab6a23522
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spelling	oai:doaj.org-article:81ac6e49487f4cfc9035cafab6a235222021-12-02T15:10:34ZLipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency10.1038/s41598-021-93817-12045-2322https://doaj.org/article/81ac6e49487f4cfc9035cafab6a235222021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93817-1https://doaj.org/toc/2045-2322Abstract The nasal mucosa (NM) contains olfactory mucosa which contributes to the detection of odorant molecules and the transmission of olfactory information to the brain. To date, the lipid composition of the human NM has not been adequately characterized. Using gas chromatography, liquid chromatography coupled to mass spectrometry and thin layer chromatography, we analyzed the fatty acids and the phospholipid and ceramide molecular species in adult human nasal and blood biopsies. Saturated and polyunsaturated fatty acids (PUFAs) accounted for 45% and 29% of the nasal total fatty acids, respectively. Fatty acids of the n-6 family were predominant in the PUFA subgroup. Linoleic acid and arachidonic acid (AA) were incorporated in the main nasal phospholipid classes. Correlation analysis revealed that the nasal AA level might be positively associated with olfactory deficiency. In addition, a strong positive association between the AA levels in the NM and in plasma cholesteryl esters suggested that this blood fraction might be used as an indicator of the nasal AA level. The most abundant species of ceramides and their glycosylated derivatives detected in NM contained palmitic acid and long-chain fatty acids. Overall, this study provides new insight into lipid species that potentially contribute to the maintenance of NM homeostasis and demonstrates that circulating biomarkers might be used to predict nasal fatty acid content.Spiro KhouryVolker GudziolStéphane GrégoireStéphanie CabaretSusanne MenzelLucy MartineEsther MézièreVanessa SoubeyreThierry Thomas-DanguinXavier GrosmaitreLionel BretillonOlivier BerdeauxNiyazi AcarThomas HummelAnne Marie Le BonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Spiro Khoury Volker Gudziol Stéphane Grégoire Stéphanie Cabaret Susanne Menzel Lucy Martine Esther Mézière Vanessa Soubeyre Thierry Thomas-Danguin Xavier Grosmaitre Lionel Bretillon Olivier Berdeaux Niyazi Acar Thomas Hummel Anne Marie Le Bon Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency
description	Abstract The nasal mucosa (NM) contains olfactory mucosa which contributes to the detection of odorant molecules and the transmission of olfactory information to the brain. To date, the lipid composition of the human NM has not been adequately characterized. Using gas chromatography, liquid chromatography coupled to mass spectrometry and thin layer chromatography, we analyzed the fatty acids and the phospholipid and ceramide molecular species in adult human nasal and blood biopsies. Saturated and polyunsaturated fatty acids (PUFAs) accounted for 45% and 29% of the nasal total fatty acids, respectively. Fatty acids of the n-6 family were predominant in the PUFA subgroup. Linoleic acid and arachidonic acid (AA) were incorporated in the main nasal phospholipid classes. Correlation analysis revealed that the nasal AA level might be positively associated with olfactory deficiency. In addition, a strong positive association between the AA levels in the NM and in plasma cholesteryl esters suggested that this blood fraction might be used as an indicator of the nasal AA level. The most abundant species of ceramides and their glycosylated derivatives detected in NM contained palmitic acid and long-chain fatty acids. Overall, this study provides new insight into lipid species that potentially contribute to the maintenance of NM homeostasis and demonstrates that circulating biomarkers might be used to predict nasal fatty acid content.
format	article
author	Spiro Khoury Volker Gudziol Stéphane Grégoire Stéphanie Cabaret Susanne Menzel Lucy Martine Esther Mézière Vanessa Soubeyre Thierry Thomas-Danguin Xavier Grosmaitre Lionel Bretillon Olivier Berdeaux Niyazi Acar Thomas Hummel Anne Marie Le Bon
author_facet	Spiro Khoury Volker Gudziol Stéphane Grégoire Stéphanie Cabaret Susanne Menzel Lucy Martine Esther Mézière Vanessa Soubeyre Thierry Thomas-Danguin Xavier Grosmaitre Lionel Bretillon Olivier Berdeaux Niyazi Acar Thomas Hummel Anne Marie Le Bon
author_sort	Spiro Khoury
title	Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency
title_short	Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency
title_full	Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency
title_fullStr	Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency
title_full_unstemmed	Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency
title_sort	lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81ac6e49487f4cfc9035cafab6a23522
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Lipidomic profile of human nasal mucosa and associations with circulating fatty acids and olfactory deficiency

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