SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation

SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation

Cancer stem-like cells are the culprits of tumour recurrence and metastasis, but their regulatory mechanisms are not fully understood. Here, the authors show that the scaffold protein SH3RF3 enhances the stem-like properties of breast cancer by facilitating activation of the JNK-JUN pathway and PTX3...

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Autores principales: Peiyuan Zhang, Yingjie Liu, Cheng Lian, Xuan Cao, Yuan Wang, Xiaoxun Li, Min Cong, Pu Tian, Xue Zhang, Gang Wei, Tong Liu, Guohong Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/81ad87ac263146be82ad92faacf965be
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spelling oai:doaj.org-article:81ad87ac263146be82ad92faacf965be2021-12-02T15:52:52ZSH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation10.1038/s41467-020-16051-92041-1723https://doaj.org/article/81ad87ac263146be82ad92faacf965be2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16051-9https://doaj.org/toc/2041-1723Cancer stem-like cells are the culprits of tumour recurrence and metastasis, but their regulatory mechanisms are not fully understood. Here, the authors show that the scaffold protein SH3RF3 enhances the stem-like properties of breast cancer by facilitating activation of the JNK-JUN pathway and PTX3 expression.Peiyuan ZhangYingjie LiuCheng LianXuan CaoYuan WangXiaoxun LiMin CongPu TianXue ZhangGang WeiTong LiuGuohong HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Peiyuan Zhang
Yingjie Liu
Cheng Lian
Xuan Cao
Yuan Wang
Xiaoxun Li
Min Cong
Pu Tian
Xue Zhang
Gang Wei
Tong Liu
Guohong Hu
SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
description Cancer stem-like cells are the culprits of tumour recurrence and metastasis, but their regulatory mechanisms are not fully understood. Here, the authors show that the scaffold protein SH3RF3 enhances the stem-like properties of breast cancer by facilitating activation of the JNK-JUN pathway and PTX3 expression.
format article
author Peiyuan Zhang
Yingjie Liu
Cheng Lian
Xuan Cao
Yuan Wang
Xiaoxun Li
Min Cong
Pu Tian
Xue Zhang
Gang Wei
Tong Liu
Guohong Hu
author_facet Peiyuan Zhang
Yingjie Liu
Cheng Lian
Xuan Cao
Yuan Wang
Xiaoxun Li
Min Cong
Pu Tian
Xue Zhang
Gang Wei
Tong Liu
Guohong Hu
author_sort Peiyuan Zhang
title SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
title_short SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
title_full SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
title_fullStr SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
title_full_unstemmed SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
title_sort sh3rf3 promotes breast cancer stem-like properties via jnk activation and ptx3 upregulation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/81ad87ac263146be82ad92faacf965be
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