Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

Alphaviruses need to selectively package genomic viral RNA for transmission, but the packaging mechanism remains unclear. Here, Brown et al. combine PAR-CLIP with biotinylated capsid protein (Cp) retrieval and identify multiple Cp binding sites on genomic viral RNA that promote virion formation.

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Autores principales:	Rebecca S. Brown, Dimitrios G. Anastasakis, Markus Hafner, Margaret Kielian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81af71b108cf49c58d849e413ef24f8d
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spelling	oai:doaj.org-article:81af71b108cf49c58d849e413ef24f8d2021-12-02T17:23:48ZMultiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA10.1038/s41467-020-18447-z2041-1723https://doaj.org/article/81af71b108cf49c58d849e413ef24f8d2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18447-zhttps://doaj.org/toc/2041-1723Alphaviruses need to selectively package genomic viral RNA for transmission, but the packaging mechanism remains unclear. Here, Brown et al. combine PAR-CLIP with biotinylated capsid protein (Cp) retrieval and identify multiple Cp binding sites on genomic viral RNA that promote virion formation.Rebecca S. BrownDimitrios G. AnastasakisMarkus HafnerMargaret KielianNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca S. Brown Dimitrios G. Anastasakis Markus Hafner Margaret Kielian Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA
description	Alphaviruses need to selectively package genomic viral RNA for transmission, but the packaging mechanism remains unclear. Here, Brown et al. combine PAR-CLIP with biotinylated capsid protein (Cp) retrieval and identify multiple Cp binding sites on genomic viral RNA that promote virion formation.
format	article
author	Rebecca S. Brown Dimitrios G. Anastasakis Markus Hafner Margaret Kielian
author_facet	Rebecca S. Brown Dimitrios G. Anastasakis Markus Hafner Margaret Kielian
author_sort	Rebecca S. Brown
title	Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA
title_short	Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA
title_full	Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA
title_fullStr	Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA
title_full_unstemmed	Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA
title_sort	multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic rna
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/81af71b108cf49c58d849e413ef24f8d
work_keys_str_mv	AT rebeccasbrown multiplecapsidproteinbindingsitesmediateselectivepackagingofthealphavirusgenomicrna AT dimitriosganastasakis multiplecapsidproteinbindingsitesmediateselectivepackagingofthealphavirusgenomicrna AT markushafner multiplecapsidproteinbindingsitesmediateselectivepackagingofthealphavirusgenomicrna AT margaretkielian multiplecapsidproteinbindingsitesmediateselectivepackagingofthealphavirusgenomicrna
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Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

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