Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.

Certain pathogens deliver effectors into plant cells to modify host protein targets and thereby suppress immunity. These target modifications can be detected by intracellular immune receptors, or Resistance (R) proteins, that trigger strong immune responses including localized host cell death. The a...

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Autores principales:	Kristoffer Palma, Stephan Thorgrimsen, Frederikke Gro Malinovsky, Berthe Katrine Fiil, H Bjørn Nielsen, Peter Brodersen, Daniel Hofius, Morten Petersen, John Mundy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/81b1cd5bc0de42a3987ec3b633a1ce8b
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spelling	oai:doaj.org-article:81b1cd5bc0de42a3987ec3b633a1ce8b2021-11-18T06:03:50ZAutoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.1553-73661553-737410.1371/journal.ppat.1001137https://doaj.org/article/81b1cd5bc0de42a3987ec3b633a1ce8b2010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20949080/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Certain pathogens deliver effectors into plant cells to modify host protein targets and thereby suppress immunity. These target modifications can be detected by intracellular immune receptors, or Resistance (R) proteins, that trigger strong immune responses including localized host cell death. The accelerated cell death 11 (acd11) "lesion mimic" mutant of Arabidopsis thaliana exhibits autoimmune phenotypes such as constitutive defense responses and cell death without pathogen perception. ACD11 encodes a putative sphingosine transfer protein, but its precise role during these processes is unknown. In a screen for lazarus (laz) mutants that suppress acd11 death we identified two genes, LAZ2 and LAZ5. LAZ2 encodes the histone lysine methyltransferase SDG8, previously shown to epigenetically regulate flowering time via modification of histone 3 (H3). LAZ5 encodes an RPS4-like R-protein, defined by several dominant negative alleles. Microarray and chromatin immunoprecipitation analyses showed that LAZ2/SDG8 is required for LAZ5 expression and H3 lysine 36 trimethylation at LAZ5 chromatin to maintain a transcriptionally active state. We hypothesize that LAZ5 triggers cell death in the absence of ACD11, and that cell death in other lesion mimic mutants may also be caused by inappropriate activation of R genes. Moreover, SDG8 is required for basal and R protein-mediated pathogen resistance in Arabidopsis, revealing the importance of chromatin remodeling as a key process in plant innate immunity.Kristoffer PalmaStephan ThorgrimsenFrederikke Gro MalinovskyBerthe Katrine FiilH Bjørn NielsenPeter BrodersenDaniel HofiusMorten PetersenJohn MundyPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 10, p e1001137 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Kristoffer Palma Stephan Thorgrimsen Frederikke Gro Malinovsky Berthe Katrine Fiil H Bjørn Nielsen Peter Brodersen Daniel Hofius Morten Petersen John Mundy Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
description	Certain pathogens deliver effectors into plant cells to modify host protein targets and thereby suppress immunity. These target modifications can be detected by intracellular immune receptors, or Resistance (R) proteins, that trigger strong immune responses including localized host cell death. The accelerated cell death 11 (acd11) "lesion mimic" mutant of Arabidopsis thaliana exhibits autoimmune phenotypes such as constitutive defense responses and cell death without pathogen perception. ACD11 encodes a putative sphingosine transfer protein, but its precise role during these processes is unknown. In a screen for lazarus (laz) mutants that suppress acd11 death we identified two genes, LAZ2 and LAZ5. LAZ2 encodes the histone lysine methyltransferase SDG8, previously shown to epigenetically regulate flowering time via modification of histone 3 (H3). LAZ5 encodes an RPS4-like R-protein, defined by several dominant negative alleles. Microarray and chromatin immunoprecipitation analyses showed that LAZ2/SDG8 is required for LAZ5 expression and H3 lysine 36 trimethylation at LAZ5 chromatin to maintain a transcriptionally active state. We hypothesize that LAZ5 triggers cell death in the absence of ACD11, and that cell death in other lesion mimic mutants may also be caused by inappropriate activation of R genes. Moreover, SDG8 is required for basal and R protein-mediated pathogen resistance in Arabidopsis, revealing the importance of chromatin remodeling as a key process in plant innate immunity.
format	article
author	Kristoffer Palma Stephan Thorgrimsen Frederikke Gro Malinovsky Berthe Katrine Fiil H Bjørn Nielsen Peter Brodersen Daniel Hofius Morten Petersen John Mundy
author_facet	Kristoffer Palma Stephan Thorgrimsen Frederikke Gro Malinovsky Berthe Katrine Fiil H Bjørn Nielsen Peter Brodersen Daniel Hofius Morten Petersen John Mundy
author_sort	Kristoffer Palma
title	Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
title_short	Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
title_full	Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
title_fullStr	Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
title_full_unstemmed	Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
title_sort	autoimmunity in arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/81b1cd5bc0de42a3987ec3b633a1ce8b
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Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.

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