Changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression

Jie Gao, Wei Xu, Kun Han, Lu Zhu, Lili Gao, Xiuli Shang Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China Background: This was a longitudinal study which investigated the relationship between serum uric acid (SUA) and total bilirubin (Tbil) upon admi...

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Autores principales:	Gao J, Xu W, Han K, Zhu L, Gao L, Shang XL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Depression after stroke Stroke Total bilirubin Uric acid Longitudinal study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/81b2875125ac4609a6709f19671e1199
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spelling	oai:doaj.org-article:81b2875125ac4609a6709f19671e11992021-12-02T03:01:48ZChanges of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression1178-2021https://doaj.org/article/81b2875125ac4609a6709f19671e11992017-12-01T00:00:00Zhttps://www.dovepress.com/changes-of-serum-uric-acid-and-total-bilirubin-in-elderly-patients-wit-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jie Gao, Wei Xu, Kun Han, Lu Zhu, Lili Gao, Xiuli Shang Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China Background: This was a longitudinal study which investigated the relationship between serum uric acid (SUA) and total bilirubin (Tbil) upon admission in elderly stroke patients and the occurrence of postischemic stroke depression (IPSD) at 3, 6, and 9 months of post-stroke follow-up. Subjects and methods: Data were analyzed for 525 acute ischemic stroke patients. Beck Depression Inventory (BDI) scores >17 and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) were used separately to screen and diagnose IPSD at 3, 6, and 9 months post-stroke. Once IPSD was diagnosed, follow-up activities were terminated. Results: High levels of SUA (odds ratio [OR]=2.08, P<0.01) and Tbil (OR=2.31, P<0.01) in the first 3 months post-stroke and low levels of SUA (OR=2.05, P=0.03) and Tbil (OR=2.79, P<0.01) from 3 to 6 months post-stroke were identified as risk factors for major IPSD. At 3 months, patients with SUA levels ≥406.5 µmol/L (males with SUA levels of ≥409.5 µmol/L and females with SUA levels ≥385.5 µmol/L) and Tbil levels ≥23.65 µmol/L were more likely to develop major IPSD. At 6 months, both SUA (area under curve [AUC]=0.625, P=0.005, cutoff =194.0 µmol/L) and Tbil (AUC=0.681, P=0.004, cutoff =6.75 µmol/L) had minor diagnostic values (AUC<0.700), although SUA levels ≤214.5 µmol/L (AUC=0.756, P=0.001) in female patients had a good diagnostic value (AUC=0.722, P=0.006) for major IPSD. At 9 months, major IPSD showed no statistical relationship with either SUA (χ2=2.33, P=0.13) or Tbil (χ2=0.41, P=0.84). Conclusion: Higher levels of SUA and Tbil on admission were closely related to the occurrence of major IPSD within 3 months of stroke. Lower levels of these two biomarkers on admission were characteristic for the occurrence of major IPSD between 3 and 6 months post-stroke, while 6 months after stroke, there was no relationship between major IPSD and these two biomarkers. Keywords: depression after stroke, stroke, total bilirubin, uric acid, longitudinal studyGao JXu WHan KZhu LGao LShang XLDove Medical PressarticleDepression after strokeStrokeTotal bilirubinUric acidLongitudinal studyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 83-93 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Depression after stroke Stroke Total bilirubin Uric acid Longitudinal study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Depression after stroke Stroke Total bilirubin Uric acid Longitudinal study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gao J Xu W Han K Zhu L Gao L Shang XL Changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression
description	Jie Gao, Wei Xu, Kun Han, Lu Zhu, Lili Gao, Xiuli Shang Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China Background: This was a longitudinal study which investigated the relationship between serum uric acid (SUA) and total bilirubin (Tbil) upon admission in elderly stroke patients and the occurrence of postischemic stroke depression (IPSD) at 3, 6, and 9 months of post-stroke follow-up. Subjects and methods: Data were analyzed for 525 acute ischemic stroke patients. Beck Depression Inventory (BDI) scores >17 and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) were used separately to screen and diagnose IPSD at 3, 6, and 9 months post-stroke. Once IPSD was diagnosed, follow-up activities were terminated. Results: High levels of SUA (odds ratio [OR]=2.08, P<0.01) and Tbil (OR=2.31, P<0.01) in the first 3 months post-stroke and low levels of SUA (OR=2.05, P=0.03) and Tbil (OR=2.79, P<0.01) from 3 to 6 months post-stroke were identified as risk factors for major IPSD. At 3 months, patients with SUA levels ≥406.5 µmol/L (males with SUA levels of ≥409.5 µmol/L and females with SUA levels ≥385.5 µmol/L) and Tbil levels ≥23.65 µmol/L were more likely to develop major IPSD. At 6 months, both SUA (area under curve [AUC]=0.625, P=0.005, cutoff =194.0 µmol/L) and Tbil (AUC=0.681, P=0.004, cutoff =6.75 µmol/L) had minor diagnostic values (AUC<0.700), although SUA levels ≤214.5 µmol/L (AUC=0.756, P=0.001) in female patients had a good diagnostic value (AUC=0.722, P=0.006) for major IPSD. At 9 months, major IPSD showed no statistical relationship with either SUA (χ2=2.33, P=0.13) or Tbil (χ2=0.41, P=0.84). Conclusion: Higher levels of SUA and Tbil on admission were closely related to the occurrence of major IPSD within 3 months of stroke. Lower levels of these two biomarkers on admission were characteristic for the occurrence of major IPSD between 3 and 6 months post-stroke, while 6 months after stroke, there was no relationship between major IPSD and these two biomarkers. Keywords: depression after stroke, stroke, total bilirubin, uric acid, longitudinal study
format	article
author	Gao J Xu W Han K Zhu L Gao L Shang XL
author_facet	Gao J Xu W Han K Zhu L Gao L Shang XL
author_sort	Gao J
title	Changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression
title_short	Changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression
title_full	Changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression
title_fullStr	Changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression
title_full_unstemmed	Changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression
title_sort	changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/81b2875125ac4609a6709f19671e1199
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Changes of serum uric acid and total bilirubin in elderly patients with major postischemic stroke depression

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