mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

mTORC2 activates Akt, a regulator of cell growth and metabolism, however, the role of mTORC2 in adipocytes is incompletely understood. Here the authors report that a mTORC2-Akt axis specifically activates ACLY to promote lipid synthesis and histone acetylation during brown adipocyte differentiation.

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Autores principales: C. Martinez Calejman, S. Trefely, S. W. Entwisle, A. Luciano, S. M. Jung, W. Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villén, K. E. Wellen, D. A. Guertin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/81b2d4b49afe452392aeab8cf473f847
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spelling oai:doaj.org-article:81b2d4b49afe452392aeab8cf473f8472021-12-02T15:37:11ZmTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis10.1038/s41467-020-14430-w2041-1723https://doaj.org/article/81b2d4b49afe452392aeab8cf473f8472020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14430-whttps://doaj.org/toc/2041-1723mTORC2 activates Akt, a regulator of cell growth and metabolism, however, the role of mTORC2 in adipocytes is incompletely understood. Here the authors report that a mTORC2-Akt axis specifically activates ACLY to promote lipid synthesis and histone acetylation during brown adipocyte differentiation.C. Martinez CalejmanS. TrefelyS. W. EntwisleA. LucianoS. M. JungW. HsiaoA. TorresC. M. HungH. LiN. W. SnyderJ. VillénK. E. WellenD. A. GuertinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
C. Martinez Calejman
S. Trefely
S. W. Entwisle
A. Luciano
S. M. Jung
W. Hsiao
A. Torres
C. M. Hung
H. Li
N. W. Snyder
J. Villén
K. E. Wellen
D. A. Guertin
mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
description mTORC2 activates Akt, a regulator of cell growth and metabolism, however, the role of mTORC2 in adipocytes is incompletely understood. Here the authors report that a mTORC2-Akt axis specifically activates ACLY to promote lipid synthesis and histone acetylation during brown adipocyte differentiation.
format article
author C. Martinez Calejman
S. Trefely
S. W. Entwisle
A. Luciano
S. M. Jung
W. Hsiao
A. Torres
C. M. Hung
H. Li
N. W. Snyder
J. Villén
K. E. Wellen
D. A. Guertin
author_facet C. Martinez Calejman
S. Trefely
S. W. Entwisle
A. Luciano
S. M. Jung
W. Hsiao
A. Torres
C. M. Hung
H. Li
N. W. Snyder
J. Villén
K. E. Wellen
D. A. Guertin
author_sort C. Martinez Calejman
title mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
title_short mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
title_full mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
title_fullStr mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
title_full_unstemmed mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
title_sort mtorc2-akt signaling to atp-citrate lyase drives brown adipogenesis and de novo lipogenesis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/81b2d4b49afe452392aeab8cf473f847
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