Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Activation of autophagy, via the transcription factor TFEB, is a promising strategy to treat metabolic diseases. Here, the authors report three novel classes of small molecules that promote TFEB nuclear translocation, and provide evidence for the therapeutic efficacy of these compounds in mice and w...

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Autores principales:	Chensu Wang, Hanspeter Niederstrasser, Peter M. Douglas, Rueyling Lin, Juan Jaramillo, Yang Li, Nathaniel W. Oswald, Anwu Zhou, Elizabeth A. McMillan, Saurabh Mendiratta, Zhaohui Wang, Tian Zhao, Zhiqaing Lin, Min Luo, Gang Huang, Rolf A. Brekken, Bruce A. Posner, John B. MacMillan, Jinming Gao, Michael A. White
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81b35dd22d994409b4c733145887247d
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spelling	oai:doaj.org-article:81b35dd22d994409b4c733145887247d2021-12-02T17:01:19ZSmall-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan10.1038/s41467-017-02332-32041-1723https://doaj.org/article/81b35dd22d994409b4c733145887247d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02332-3https://doaj.org/toc/2041-1723Activation of autophagy, via the transcription factor TFEB, is a promising strategy to treat metabolic diseases. Here, the authors report three novel classes of small molecules that promote TFEB nuclear translocation, and provide evidence for the therapeutic efficacy of these compounds in mice and worms.Chensu WangHanspeter NiederstrasserPeter M. DouglasRueyling LinJuan JaramilloYang LiNathaniel W. OswaldAnwu ZhouElizabeth A. McMillanSaurabh MendirattaZhaohui WangTian ZhaoZhiqaing LinMin LuoGang HuangRolf A. BrekkenBruce A. PosnerJohn B. MacMillanJinming GaoMichael A. WhiteNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chensu Wang Hanspeter Niederstrasser Peter M. Douglas Rueyling Lin Juan Jaramillo Yang Li Nathaniel W. Oswald Anwu Zhou Elizabeth A. McMillan Saurabh Mendiratta Zhaohui Wang Tian Zhao Zhiqaing Lin Min Luo Gang Huang Rolf A. Brekken Bruce A. Posner John B. MacMillan Jinming Gao Michael A. White Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
description	Activation of autophagy, via the transcription factor TFEB, is a promising strategy to treat metabolic diseases. Here, the authors report three novel classes of small molecules that promote TFEB nuclear translocation, and provide evidence for the therapeutic efficacy of these compounds in mice and worms.
format	article
author	Chensu Wang Hanspeter Niederstrasser Peter M. Douglas Rueyling Lin Juan Jaramillo Yang Li Nathaniel W. Oswald Anwu Zhou Elizabeth A. McMillan Saurabh Mendiratta Zhaohui Wang Tian Zhao Zhiqaing Lin Min Luo Gang Huang Rolf A. Brekken Bruce A. Posner John B. MacMillan Jinming Gao Michael A. White
author_facet	Chensu Wang Hanspeter Niederstrasser Peter M. Douglas Rueyling Lin Juan Jaramillo Yang Li Nathaniel W. Oswald Anwu Zhou Elizabeth A. McMillan Saurabh Mendiratta Zhaohui Wang Tian Zhao Zhiqaing Lin Min Luo Gang Huang Rolf A. Brekken Bruce A. Posner John B. MacMillan Jinming Gao Michael A. White
author_sort	Chensu Wang
title	Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
title_short	Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
title_full	Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
title_fullStr	Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
title_full_unstemmed	Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan
title_sort	small-molecule tfeb pathway agonists that ameliorate metabolic syndrome in mice and extend c. elegans lifespan
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/81b35dd22d994409b4c733145887247d
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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

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