Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma

Osteosarcoma is an aggressive tumour and little is known the mechanisms underpinning its highly metastatic nature. Here, the authors highlight a role for the CK1α/CBX4 axis in driving metastasis, suggesting that this pathway might be targeted for therapeutic benefit.

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Autores principales:	Xin Wang, Ge Qin, Xiaoting Liang, Wen Wang, Zhuo Wang, Dan Liao, Li Zhong, Ruhua Zhang, Yi-Xin Zeng, Yuanzhong Wu, Tiebang Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81b4b922e62c43c09d427d7c2872a2d6
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spelling	oai:doaj.org-article:81b4b922e62c43c09d427d7c2872a2d62021-12-02T17:32:42ZTargeting the CK1α/CBX4 axis for metastasis in osteosarcoma10.1038/s41467-020-14870-42041-1723https://doaj.org/article/81b4b922e62c43c09d427d7c2872a2d62020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14870-4https://doaj.org/toc/2041-1723Osteosarcoma is an aggressive tumour and little is known the mechanisms underpinning its highly metastatic nature. Here, the authors highlight a role for the CK1α/CBX4 axis in driving metastasis, suggesting that this pathway might be targeted for therapeutic benefit.Xin WangGe QinXiaoting LiangWen WangZhuo WangDan LiaoLi ZhongRuhua ZhangYi-Xin ZengYuanzhong WuTiebang KangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Wang Ge Qin Xiaoting Liang Wen Wang Zhuo Wang Dan Liao Li Zhong Ruhua Zhang Yi-Xin Zeng Yuanzhong Wu Tiebang Kang Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
description	Osteosarcoma is an aggressive tumour and little is known the mechanisms underpinning its highly metastatic nature. Here, the authors highlight a role for the CK1α/CBX4 axis in driving metastasis, suggesting that this pathway might be targeted for therapeutic benefit.
format	article
author	Xin Wang Ge Qin Xiaoting Liang Wen Wang Zhuo Wang Dan Liao Li Zhong Ruhua Zhang Yi-Xin Zeng Yuanzhong Wu Tiebang Kang
author_facet	Xin Wang Ge Qin Xiaoting Liang Wen Wang Zhuo Wang Dan Liao Li Zhong Ruhua Zhang Yi-Xin Zeng Yuanzhong Wu Tiebang Kang
author_sort	Xin Wang
title	Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
title_short	Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
title_full	Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
title_fullStr	Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
title_full_unstemmed	Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
title_sort	targeting the ck1α/cbx4 axis for metastasis in osteosarcoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/81b4b922e62c43c09d427d7c2872a2d6
work_keys_str_mv	AT xinwang targetingtheck1acbx4axisformetastasisinosteosarcoma AT geqin targetingtheck1acbx4axisformetastasisinosteosarcoma AT xiaotingliang targetingtheck1acbx4axisformetastasisinosteosarcoma AT wenwang targetingtheck1acbx4axisformetastasisinosteosarcoma AT zhuowang targetingtheck1acbx4axisformetastasisinosteosarcoma AT danliao targetingtheck1acbx4axisformetastasisinosteosarcoma AT lizhong targetingtheck1acbx4axisformetastasisinosteosarcoma AT ruhuazhang targetingtheck1acbx4axisformetastasisinosteosarcoma AT yixinzeng targetingtheck1acbx4axisformetastasisinosteosarcoma AT yuanzhongwu targetingtheck1acbx4axisformetastasisinosteosarcoma AT tiebangkang targetingtheck1acbx4axisformetastasisinosteosarcoma
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Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma

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