Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

While proinflammatory signalling is preventive to axon regrowth, activated macrophages can be beneficial, for example by limiting the inflammation. This study uses mutant zebrafish lines that lack macrophages and/or microglia to show that peripheral macrophages are necessary in axon regrowth followi...

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Autores principales: Themistoklis M. Tsarouchas, Daniel Wehner, Leonardo Cavone, Tahimina Munir, Marcus Keatinge, Marvin Lambertus, Anna Underhill, Thomas Barrett, Elias Kassapis, Nikolay Ogryzko, Yi Feng, Tjakko J. van Ham, Thomas Becker, Catherina G. Becker
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/81b50b2041a6448a84c8fcb25d9591a7
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spelling oai:doaj.org-article:81b50b2041a6448a84c8fcb25d9591a72021-12-02T15:33:43ZDynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration10.1038/s41467-018-07036-w2041-1723https://doaj.org/article/81b50b2041a6448a84c8fcb25d9591a72018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07036-whttps://doaj.org/toc/2041-1723While proinflammatory signalling is preventive to axon regrowth, activated macrophages can be beneficial, for example by limiting the inflammation. This study uses mutant zebrafish lines that lack macrophages and/or microglia to show that peripheral macrophages are necessary in axon regrowth following complete transection of spinal cord.Themistoklis M. TsarouchasDaniel WehnerLeonardo CavoneTahimina MunirMarcus KeatingeMarvin LambertusAnna UnderhillThomas BarrettElias KassapisNikolay OgryzkoYi FengTjakko J. van HamThomas BeckerCatherina G. BeckerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Themistoklis M. Tsarouchas
Daniel Wehner
Leonardo Cavone
Tahimina Munir
Marcus Keatinge
Marvin Lambertus
Anna Underhill
Thomas Barrett
Elias Kassapis
Nikolay Ogryzko
Yi Feng
Tjakko J. van Ham
Thomas Becker
Catherina G. Becker
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
description While proinflammatory signalling is preventive to axon regrowth, activated macrophages can be beneficial, for example by limiting the inflammation. This study uses mutant zebrafish lines that lack macrophages and/or microglia to show that peripheral macrophages are necessary in axon regrowth following complete transection of spinal cord.
format article
author Themistoklis M. Tsarouchas
Daniel Wehner
Leonardo Cavone
Tahimina Munir
Marcus Keatinge
Marvin Lambertus
Anna Underhill
Thomas Barrett
Elias Kassapis
Nikolay Ogryzko
Yi Feng
Tjakko J. van Ham
Thomas Becker
Catherina G. Becker
author_facet Themistoklis M. Tsarouchas
Daniel Wehner
Leonardo Cavone
Tahimina Munir
Marcus Keatinge
Marvin Lambertus
Anna Underhill
Thomas Barrett
Elias Kassapis
Nikolay Ogryzko
Yi Feng
Tjakko J. van Ham
Thomas Becker
Catherina G. Becker
author_sort Themistoklis M. Tsarouchas
title Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_short Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_full Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_fullStr Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_full_unstemmed Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_sort dynamic control of proinflammatory cytokines il-1β and tnf-α by macrophages in zebrafish spinal cord regeneration
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/81b50b2041a6448a84c8fcb25d9591a7
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