Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

While proinflammatory signalling is preventive to axon regrowth, activated macrophages can be beneficial, for example by limiting the inflammation. This study uses mutant zebrafish lines that lack macrophages and/or microglia to show that peripheral macrophages are necessary in axon regrowth followi...

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Auteurs principaux:	Themistoklis M. Tsarouchas, Daniel Wehner, Leonardo Cavone, Tahimina Munir, Marcus Keatinge, Marvin Lambertus, Anna Underhill, Thomas Barrett, Elias Kassapis, Nikolay Ogryzko, Yi Feng, Tjakko J. van Ham, Thomas Becker, Catherina G. Becker
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/81b50b2041a6448a84c8fcb25d9591a7
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spelling	oai:doaj.org-article:81b50b2041a6448a84c8fcb25d9591a72021-12-02T15:33:43ZDynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration10.1038/s41467-018-07036-w2041-1723https://doaj.org/article/81b50b2041a6448a84c8fcb25d9591a72018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07036-whttps://doaj.org/toc/2041-1723While proinflammatory signalling is preventive to axon regrowth, activated macrophages can be beneficial, for example by limiting the inflammation. This study uses mutant zebrafish lines that lack macrophages and/or microglia to show that peripheral macrophages are necessary in axon regrowth following complete transection of spinal cord.Themistoklis M. TsarouchasDaniel WehnerLeonardo CavoneTahimina MunirMarcus KeatingeMarvin LambertusAnna UnderhillThomas BarrettElias KassapisNikolay OgryzkoYi FengTjakko J. van HamThomas BeckerCatherina G. BeckerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Themistoklis M. Tsarouchas Daniel Wehner Leonardo Cavone Tahimina Munir Marcus Keatinge Marvin Lambertus Anna Underhill Thomas Barrett Elias Kassapis Nikolay Ogryzko Yi Feng Tjakko J. van Ham Thomas Becker Catherina G. Becker Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
description	While proinflammatory signalling is preventive to axon regrowth, activated macrophages can be beneficial, for example by limiting the inflammation. This study uses mutant zebrafish lines that lack macrophages and/or microglia to show that peripheral macrophages are necessary in axon regrowth following complete transection of spinal cord.
format	article
author	Themistoklis M. Tsarouchas Daniel Wehner Leonardo Cavone Tahimina Munir Marcus Keatinge Marvin Lambertus Anna Underhill Thomas Barrett Elias Kassapis Nikolay Ogryzko Yi Feng Tjakko J. van Ham Thomas Becker Catherina G. Becker
author_facet	Themistoklis M. Tsarouchas Daniel Wehner Leonardo Cavone Tahimina Munir Marcus Keatinge Marvin Lambertus Anna Underhill Thomas Barrett Elias Kassapis Nikolay Ogryzko Yi Feng Tjakko J. van Ham Thomas Becker Catherina G. Becker
author_sort	Themistoklis M. Tsarouchas
title	Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_short	Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_full	Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_fullStr	Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_full_unstemmed	Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
title_sort	dynamic control of proinflammatory cytokines il-1β and tnf-α by macrophages in zebrafish spinal cord regeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/81b50b2041a6448a84c8fcb25d9591a7
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Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

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