The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening

Abstract An interval breast cancer is a cancer that emerges following a negative mammographic screen. This overview describes the epidemiology, and the radiological and biological characteristics of interval breast cancers in population mammography screening. Notwithstanding possible differences in...

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Autores principales:	Nehmat Houssami, Kylie Hunter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/81b6426aee1648c9ae6b1fbf87134cbf
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spelling	oai:doaj.org-article:81b6426aee1648c9ae6b1fbf87134cbf2021-12-02T16:19:49ZThe epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening10.1038/s41523-017-0014-x2374-4677https://doaj.org/article/81b6426aee1648c9ae6b1fbf87134cbf2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0014-xhttps://doaj.org/toc/2374-4677Abstract An interval breast cancer is a cancer that emerges following a negative mammographic screen. This overview describes the epidemiology, and the radiological and biological characteristics of interval breast cancers in population mammography screening. Notwithstanding possible differences in ascertainment of interval breast cancers, there was broad variability in reported interval breast cancer rates (range 7.0 to 49.3 per 10,000 screens) reflecting heterogeneity in underlying breast cancer rates, screening rounds (initial or repeat screens), and the length and phase of the inter-screening interval. The majority of studies (based on biennial screening) reported interval breast cancer rates in the range of 8.4 to 21.1 per 10,000 screens spanning the two-year interval with the larger proportion occurring in the second year. Despite methodological limitations inherent in radiological surveillance (retrospective mammographic review) of interval breast cancers, this form of surveillance consistently reveals that the majority of interval cancers represent either true interval or occult cancers that were not visible on the index mammographic screen; approximately 20–25% of interval breast cancers are classified as having been missed (false-negatives). The biological characteristics of interval breast cancers show that they have relatively worse tumour prognostic characteristics and biomarker profile, and also survival outcomes, than screen-detected breast cancers; however, they have similar characteristics and prognosis as breast cancers occurring in non-screened women. There was limited evidence on the effect on interval breast cancer frequency and outcomes following transition from film to digital mammography screening.Nehmat HoussamiKylie HunterNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nehmat Houssami Kylie Hunter The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening
description	Abstract An interval breast cancer is a cancer that emerges following a negative mammographic screen. This overview describes the epidemiology, and the radiological and biological characteristics of interval breast cancers in population mammography screening. Notwithstanding possible differences in ascertainment of interval breast cancers, there was broad variability in reported interval breast cancer rates (range 7.0 to 49.3 per 10,000 screens) reflecting heterogeneity in underlying breast cancer rates, screening rounds (initial or repeat screens), and the length and phase of the inter-screening interval. The majority of studies (based on biennial screening) reported interval breast cancer rates in the range of 8.4 to 21.1 per 10,000 screens spanning the two-year interval with the larger proportion occurring in the second year. Despite methodological limitations inherent in radiological surveillance (retrospective mammographic review) of interval breast cancers, this form of surveillance consistently reveals that the majority of interval cancers represent either true interval or occult cancers that were not visible on the index mammographic screen; approximately 20–25% of interval breast cancers are classified as having been missed (false-negatives). The biological characteristics of interval breast cancers show that they have relatively worse tumour prognostic characteristics and biomarker profile, and also survival outcomes, than screen-detected breast cancers; however, they have similar characteristics and prognosis as breast cancers occurring in non-screened women. There was limited evidence on the effect on interval breast cancer frequency and outcomes following transition from film to digital mammography screening.
format	article
author	Nehmat Houssami Kylie Hunter
author_facet	Nehmat Houssami Kylie Hunter
author_sort	Nehmat Houssami
title	The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening
title_short	The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening
title_full	The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening
title_fullStr	The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening
title_full_unstemmed	The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening
title_sort	epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/81b6426aee1648c9ae6b1fbf87134cbf
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The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening

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