Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)

Currently, morbidity and mortality from chronic diffuse diseases of the liver and cirrhosis continue to increase worldwide. The difficulty of stabilizing the process with pharmacological agents, lots of restrictions for liver transplantation, the palliative character of the surgical correction of co...

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Autores principales:	I. R. Vesir, G. Ts. Dambaev, V. E. Gunter, E. A. Gereng, A. N. Vusik, N. E. Kurtseitov, M. M. Solovev, O. A. Fatushina, E. A. Avdoshina, I. M. Mominov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	liver regeneration stimulation of regeneration nickel titanium Science Q
Acceso en línea:	https://doaj.org/article/81b856a8b92d432bbf2cd16e974476f2
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spelling	oai:doaj.org-article:81b856a8b92d432bbf2cd16e974476f22021-11-23T06:14:43ZStimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)2541-94202587-959610.29413/ABS.2020-5.1.11https://doaj.org/article/81b856a8b92d432bbf2cd16e974476f22020-03-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2243https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Currently, morbidity and mortality from chronic diffuse diseases of the liver and cirrhosis continue to increase worldwide. The difficulty of stabilizing the process with pharmacological agents, lots of restrictions for liver transplantation, the palliative character of the surgical correction of complications determine the urgency of finding various ways to stimulate liver regeneration, including surgical ones. Most of the known methods of surgical stimulation of regeneration are quite traumatic, and their stimulating effect is short-lived. The methods associated with cellular technologies are mostly expensive, ineffective, or poorly understood. In the experimental study, the effect on the parenchyma of a healthy and cirrhotic liver clips for clamping parenchymal organs exerting different unit pressure on the tissue was studied. The object of the study was laboratory rats with a healthy liver and animals with simulated cirrhosis. The animals were operated on with the imposition of titanium nickelide clips on the liver. Changes in the liver were studied 3, 7, 14, and 28 days after the surgery by histological examination of various parts of the liver. It was established that the clip with a lower specific pressure did not cause tissue necrosis, led to atrophy of the marginal part of the liver, also increased hepatocytes and binuclear hepatocytes were observed in the bulk of the liver. A decrease in the proportion of connective tissue was also observed in groups with liver cirrhosis. Thus, we consider it possible to use clips with a certain specific pressure on the tissue as a method of stimulating the reparative properties of the liver in chronic diffuse diseases and cirrhosis of the liverI. R. VesirG. Ts. DambaevV. E. GunterE. A. GerengA. N. VusikN. E. KurtseitovM. M. SolovevO. A. FatushinaE. A. AvdoshinaI. M. MominovScientific Сentre for Family Health and Human Reproduction Problemsarticleliverregenerationstimulation of regenerationnickel titaniumScienceQRUActa Biomedica Scientifica, Vol 5, Iss 1, Pp 78-83 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	liver regeneration stimulation of regeneration nickel titanium Science Q
spellingShingle	liver regeneration stimulation of regeneration nickel titanium Science Q I. R. Vesir G. Ts. Dambaev V. E. Gunter E. A. Gereng A. N. Vusik N. E. Kurtseitov M. M. Solovev O. A. Fatushina E. A. Avdoshina I. M. Mominov Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)
description	Currently, morbidity and mortality from chronic diffuse diseases of the liver and cirrhosis continue to increase worldwide. The difficulty of stabilizing the process with pharmacological agents, lots of restrictions for liver transplantation, the palliative character of the surgical correction of complications determine the urgency of finding various ways to stimulate liver regeneration, including surgical ones. Most of the known methods of surgical stimulation of regeneration are quite traumatic, and their stimulating effect is short-lived. The methods associated with cellular technologies are mostly expensive, ineffective, or poorly understood. In the experimental study, the effect on the parenchyma of a healthy and cirrhotic liver clips for clamping parenchymal organs exerting different unit pressure on the tissue was studied. The object of the study was laboratory rats with a healthy liver and animals with simulated cirrhosis. The animals were operated on with the imposition of titanium nickelide clips on the liver. Changes in the liver were studied 3, 7, 14, and 28 days after the surgery by histological examination of various parts of the liver. It was established that the clip with a lower specific pressure did not cause tissue necrosis, led to atrophy of the marginal part of the liver, also increased hepatocytes and binuclear hepatocytes were observed in the bulk of the liver. A decrease in the proportion of connective tissue was also observed in groups with liver cirrhosis. Thus, we consider it possible to use clips with a certain specific pressure on the tissue as a method of stimulating the reparative properties of the liver in chronic diffuse diseases and cirrhosis of the liver
format	article
author	I. R. Vesir G. Ts. Dambaev V. E. Gunter E. A. Gereng A. N. Vusik N. E. Kurtseitov M. M. Solovev O. A. Fatushina E. A. Avdoshina I. M. Mominov
author_facet	I. R. Vesir G. Ts. Dambaev V. E. Gunter E. A. Gereng A. N. Vusik N. E. Kurtseitov M. M. Solovev O. A. Fatushina E. A. Avdoshina I. M. Mominov
author_sort	I. R. Vesir
title	Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)
title_short	Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)
title_full	Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)
title_fullStr	Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)
title_full_unstemmed	Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)
title_sort	stimulation of liver regeneration using a titanium nickelide implant (experimental study)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/81b856a8b92d432bbf2cd16e974476f2
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Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)

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