Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice

Abstract This study tests the hypothesis that an Onchocerca volvulus vaccine, consisting of two recombinant antigens (Ov-103 and Ov-RAL-2) formulated with the combination-adjuvant Advax-2, can induce protective immunity in genetically diverse Collaborative Cross recombinant inbred intercross mice (C...

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Autores principales:	Nathan M. Ryan, Jessica A. Hess, Fernando Pardo-Manuel de Villena, Benjamin E. Leiby, Ayako Shimada, Lei Yu, Amir Yarmahmoodi, Nikolai Petrovsky, Bin Zhan, Maria Elena Bottazzi, Benjamin L. Makepeace, Sara Lustigman, David Abraham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/81bbb94a2d7b4f9fa3b415ead7d31ec9
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spelling	oai:doaj.org-article:81bbb94a2d7b4f9fa3b415ead7d31ec92021-12-02T14:16:48ZOnchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice10.1038/s41541-020-00276-22059-0105https://doaj.org/article/81bbb94a2d7b4f9fa3b415ead7d31ec92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41541-020-00276-2https://doaj.org/toc/2059-0105Abstract This study tests the hypothesis that an Onchocerca volvulus vaccine, consisting of two recombinant antigens (Ov-103 and Ov-RAL-2) formulated with the combination-adjuvant Advax-2, can induce protective immunity in genetically diverse Collaborative Cross recombinant inbred intercross mice (CC-RIX). CC-RIX lines were immunized with the O. volvulus vaccine and challenged with third-stage larvae. Equal and significant reductions in parasite survival were observed in 7 of 8 CC-RIX lines. Innate protective immunity was seen in the single CC-RIX line that did not demonstrate protective adaptive immunity. Analysis of a wide array of immune factors showed that each line of mice have a unique set of immune responses to vaccination and challenge suggesting that the vaccine is polyfunctional, inducing different equally-protective sets of immune responses based on the genetic background of the immunized host. Vaccine efficacy in genetically diverse mice suggests that it will also be effective in genetically complex human populations.Nathan M. RyanJessica A. HessFernando Pardo-Manuel de VillenaBenjamin E. LeibyAyako ShimadaLei YuAmir YarmahmoodiNikolai PetrovskyBin ZhanMaria Elena BottazziBenjamin L. MakepeaceSara LustigmanDavid AbrahamNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nathan M. Ryan Jessica A. Hess Fernando Pardo-Manuel de Villena Benjamin E. Leiby Ayako Shimada Lei Yu Amir Yarmahmoodi Nikolai Petrovsky Bin Zhan Maria Elena Bottazzi Benjamin L. Makepeace Sara Lustigman David Abraham Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice
description	Abstract This study tests the hypothesis that an Onchocerca volvulus vaccine, consisting of two recombinant antigens (Ov-103 and Ov-RAL-2) formulated with the combination-adjuvant Advax-2, can induce protective immunity in genetically diverse Collaborative Cross recombinant inbred intercross mice (CC-RIX). CC-RIX lines were immunized with the O. volvulus vaccine and challenged with third-stage larvae. Equal and significant reductions in parasite survival were observed in 7 of 8 CC-RIX lines. Innate protective immunity was seen in the single CC-RIX line that did not demonstrate protective adaptive immunity. Analysis of a wide array of immune factors showed that each line of mice have a unique set of immune responses to vaccination and challenge suggesting that the vaccine is polyfunctional, inducing different equally-protective sets of immune responses based on the genetic background of the immunized host. Vaccine efficacy in genetically diverse mice suggests that it will also be effective in genetically complex human populations.
format	article
author	Nathan M. Ryan Jessica A. Hess Fernando Pardo-Manuel de Villena Benjamin E. Leiby Ayako Shimada Lei Yu Amir Yarmahmoodi Nikolai Petrovsky Bin Zhan Maria Elena Bottazzi Benjamin L. Makepeace Sara Lustigman David Abraham
author_facet	Nathan M. Ryan Jessica A. Hess Fernando Pardo-Manuel de Villena Benjamin E. Leiby Ayako Shimada Lei Yu Amir Yarmahmoodi Nikolai Petrovsky Bin Zhan Maria Elena Bottazzi Benjamin L. Makepeace Sara Lustigman David Abraham
author_sort	Nathan M. Ryan
title	Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice
title_short	Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice
title_full	Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice
title_fullStr	Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice
title_full_unstemmed	Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice
title_sort	onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81bbb94a2d7b4f9fa3b415ead7d31ec9
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Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice

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