Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia

Study Objectives. To study the relationship between perimenopausal insomnia (PI) and intestinal flora and the potential mechanism of Tianwang Buxin granules (TWBXG) in exerting its clinical efficacy. Methods. The subjects included 13 PI patients from the Hubei Provincial Hospital of TCM, Hubei Unive...

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Autores principales:	Xiqian Yang, Hesong Xiao, Yi Zeng, Liangliang Huang, Ke Ji, Diyang Deng, Wenyu Yang, Ling Liu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/81bbe894d7684b4aaf6bd75b360aafbe
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spelling	oai:doaj.org-article:81bbe894d7684b4aaf6bd75b360aafbe2021-11-29T00:57:06ZTianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia2314-614110.1155/2021/9979511https://doaj.org/article/81bbe894d7684b4aaf6bd75b360aafbe2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9979511https://doaj.org/toc/2314-6141Study Objectives. To study the relationship between perimenopausal insomnia (PI) and intestinal flora and the potential mechanism of Tianwang Buxin granules (TWBXG) in exerting its clinical efficacy. Methods. The subjects included 13 PI patients from the Hubei Provincial Hospital of TCM, Hubei University of TCM, and Wuhan Traditional Chinese Medicine Hospital, and the corresponding noninsomniac spouses of the patients were selected as controls. TWBXG was continuously administered for 4 weeks. The feces of PI patients and their noninsomniac spouses before and after treatment with TWBXG were collected. The intestinal flora composition of each group was detected by metagenomic sequencing, and the efficacy of TWBXG was evaluated by the PSQI scale. Results. Compared with the control group, the model group showed an increase in the abundance of Roseburia faecis, Ruminococcus, Prevotella copri, Fusicatenibacter saccharivorans, and Blautia obeum, while those of Bacteroides, fecal Bacteroidetes, and Faecalibacterium prausnitzii were decreased. Compared with pretreatment, the PSQI score was significantly reduced (P<0.05), the abundance of Bacteroides, fecal Bacteroidetes, and Faecalibacterium prausnitzii increased, and that of Roseburia faecis, Ruminococcus, Prevotella copri, Fusicatenibacter saccharivorans, and Blautia obeum decreased after treatment. However, there was still a certain gap in the abundance of related flora in the treatment group compared with the control. Conclusion. PI is associated with disturbances in the intestinal flora and is mainly related to the disorders of Roseburia faecis, Ruminococcus, Prevotella copri, Fusicatenibacter saccharivorans, Blautia obeum, Bacteroides, fecal Bacteroidetes, and Faecalibacterium prausnitzii. TWBXG can effectively treat PI, and its effect may be achieved by regulating the disordered intestinal flora. Clinical Trials. The study was registered in the Chinese clinical trial registry and approved by the World Health Organization clinical trial registration platform (Effects of the modified Tianwang Buxin granule and modified Tianwang Buxin decoction pieces on insomnia: a randomized, controlled trial, ChiCTR-IPR-17011549).Xiqian YangHesong XiaoYi ZengLiangliang HuangKe JiDiyang DengWenyu YangLing LiuHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Xiqian Yang Hesong Xiao Yi Zeng Liangliang Huang Ke Ji Diyang Deng Wenyu Yang Ling Liu Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia
description	Study Objectives. To study the relationship between perimenopausal insomnia (PI) and intestinal flora and the potential mechanism of Tianwang Buxin granules (TWBXG) in exerting its clinical efficacy. Methods. The subjects included 13 PI patients from the Hubei Provincial Hospital of TCM, Hubei University of TCM, and Wuhan Traditional Chinese Medicine Hospital, and the corresponding noninsomniac spouses of the patients were selected as controls. TWBXG was continuously administered for 4 weeks. The feces of PI patients and their noninsomniac spouses before and after treatment with TWBXG were collected. The intestinal flora composition of each group was detected by metagenomic sequencing, and the efficacy of TWBXG was evaluated by the PSQI scale. Results. Compared with the control group, the model group showed an increase in the abundance of Roseburia faecis, Ruminococcus, Prevotella copri, Fusicatenibacter saccharivorans, and Blautia obeum, while those of Bacteroides, fecal Bacteroidetes, and Faecalibacterium prausnitzii were decreased. Compared with pretreatment, the PSQI score was significantly reduced (P<0.05), the abundance of Bacteroides, fecal Bacteroidetes, and Faecalibacterium prausnitzii increased, and that of Roseburia faecis, Ruminococcus, Prevotella copri, Fusicatenibacter saccharivorans, and Blautia obeum decreased after treatment. However, there was still a certain gap in the abundance of related flora in the treatment group compared with the control. Conclusion. PI is associated with disturbances in the intestinal flora and is mainly related to the disorders of Roseburia faecis, Ruminococcus, Prevotella copri, Fusicatenibacter saccharivorans, Blautia obeum, Bacteroides, fecal Bacteroidetes, and Faecalibacterium prausnitzii. TWBXG can effectively treat PI, and its effect may be achieved by regulating the disordered intestinal flora. Clinical Trials. The study was registered in the Chinese clinical trial registry and approved by the World Health Organization clinical trial registration platform (Effects of the modified Tianwang Buxin granule and modified Tianwang Buxin decoction pieces on insomnia: a randomized, controlled trial, ChiCTR-IPR-17011549).
format	article
author	Xiqian Yang Hesong Xiao Yi Zeng Liangliang Huang Ke Ji Diyang Deng Wenyu Yang Ling Liu
author_facet	Xiqian Yang Hesong Xiao Yi Zeng Liangliang Huang Ke Ji Diyang Deng Wenyu Yang Ling Liu
author_sort	Xiqian Yang
title	Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia
title_short	Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia
title_full	Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia
title_fullStr	Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia
title_full_unstemmed	Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia
title_sort	tianwang buxin granules influence the intestinal flora in perimenopausal insomnia
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/81bbe894d7684b4aaf6bd75b360aafbe
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Tianwang Buxin Granules Influence the Intestinal Flora in Perimenopausal Insomnia

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