Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia

Abstract Heme oxygenase-1 (HO-1), an inducible stress-response protein, exerts anti-oxidant and anti-apoptotic effects. However, its significance in forensic diagnosis of acute ischemic heart diseases (AIHD) such as myocardial infarction (MI) is still unknown. We examined the immunohistochemical exp...

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Autores principales:	Yumi Kuninaka, Yuko Ishida, Mizuho Nosaka, Akiko Ishigami, Akira Taruya, Emi Shimada, Akihiko Kimura, Hiroki Yamamoto, Mitsunori Ozaki, Fukumi Furukawa, Toshikazu Kondo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81bcabb01dd04be3aa201a958617d756
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spelling	oai:doaj.org-article:81bcabb01dd04be3aa201a958617d7562021-11-14T12:22:55ZForensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia10.1038/s41598-021-01102-y2045-2322https://doaj.org/article/81bcabb01dd04be3aa201a958617d7562021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01102-yhttps://doaj.org/toc/2045-2322Abstract Heme oxygenase-1 (HO-1), an inducible stress-response protein, exerts anti-oxidant and anti-apoptotic effects. However, its significance in forensic diagnosis of acute ischemic heart diseases (AIHD) such as myocardial infarction (MI) is still unknown. We examined the immunohistochemical expression of HO-1 in the heart samples to discuss their forensic significance to determine acute cardiac ischemia. The heart samples were obtained from 23 AIHD cases and 33 non-AIHD cases as controls. HO-1 positive signals in cardiomyocyte nuclear were detected in 78.2% of AIHD cases, however, that were detected in only 24.2% control cases with statistical difference between AIHD and non-AIHD groups. In contrast to HO-1 protein expression, there was no significant difference in the appearance of myoglobin pallor regions and leukocyte infiltration in the hearts between AIHD and non-AIHD groups. From the viewpoints of forensic pathology, intracardiac HO-1 expression would be considered a valuable marker to diagnose AIHD as the cause of death.Yumi KuninakaYuko IshidaMizuho NosakaAkiko IshigamiAkira TaruyaEmi ShimadaAkihiko KimuraHiroki YamamotoMitsunori OzakiFukumi FurukawaToshikazu KondoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yumi Kuninaka Yuko Ishida Mizuho Nosaka Akiko Ishigami Akira Taruya Emi Shimada Akihiko Kimura Hiroki Yamamoto Mitsunori Ozaki Fukumi Furukawa Toshikazu Kondo Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia
description	Abstract Heme oxygenase-1 (HO-1), an inducible stress-response protein, exerts anti-oxidant and anti-apoptotic effects. However, its significance in forensic diagnosis of acute ischemic heart diseases (AIHD) such as myocardial infarction (MI) is still unknown. We examined the immunohistochemical expression of HO-1 in the heart samples to discuss their forensic significance to determine acute cardiac ischemia. The heart samples were obtained from 23 AIHD cases and 33 non-AIHD cases as controls. HO-1 positive signals in cardiomyocyte nuclear were detected in 78.2% of AIHD cases, however, that were detected in only 24.2% control cases with statistical difference between AIHD and non-AIHD groups. In contrast to HO-1 protein expression, there was no significant difference in the appearance of myoglobin pallor regions and leukocyte infiltration in the hearts between AIHD and non-AIHD groups. From the viewpoints of forensic pathology, intracardiac HO-1 expression would be considered a valuable marker to diagnose AIHD as the cause of death.
format	article
author	Yumi Kuninaka Yuko Ishida Mizuho Nosaka Akiko Ishigami Akira Taruya Emi Shimada Akihiko Kimura Hiroki Yamamoto Mitsunori Ozaki Fukumi Furukawa Toshikazu Kondo
author_facet	Yumi Kuninaka Yuko Ishida Mizuho Nosaka Akiko Ishigami Akira Taruya Emi Shimada Akihiko Kimura Hiroki Yamamoto Mitsunori Ozaki Fukumi Furukawa Toshikazu Kondo
author_sort	Yumi Kuninaka
title	Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia
title_short	Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia
title_full	Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia
title_fullStr	Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia
title_full_unstemmed	Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia
title_sort	forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81bcabb01dd04be3aa201a958617d756
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Forensic significance of intracardiac heme oxygenase-1 expression in acute myocardial ischemia

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