Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules and cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-base...

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Autores principales:	Amal George Kurian, Rajendra K. Singh, Kapil D. Patel, Jung-Hwan Lee, Hae-Won Kim
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	GelMA hydrogel Nanomaterials Multifunctional Therapeutics Tissue repair Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/81bf0b5e6b234dc6a30d7fa76a092361
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id	oai:doaj.org-article:81bf0b5e6b234dc6a30d7fa76a092361
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spelling	oai:doaj.org-article:81bf0b5e6b234dc6a30d7fa76a0923612021-11-04T04:35:56ZMultifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics2452-199X10.1016/j.bioactmat.2021.06.027https://doaj.org/article/81bf0b5e6b234dc6a30d7fa76a0923612022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003133https://doaj.org/toc/2452-199XPolymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules and cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-based hydrogels have been devoted to combining them with bioactive and functional nanomaterials, aiming to provide enhanced physicochemical and biological properties to GelMA. The benefits of this approach are multiple: i) reinforcing mechanical properties, ii) modulating viscoelastic property to allow 3D printability of bio-inks, iii) rendering electrical/magnetic property to produce electro-/magneto-active hydrogels for the repair of specific tissues (e.g., muscle, nerve), iv) providing stimuli-responsiveness to actively deliver therapeutic molecules, and v) endowing therapeutic capacity in tissue repair process (e.g., antioxidant effects). The nanomaterial-combined GelMA systems have shown significantly enhanced and extraordinary behaviors in various tissues (bone, skin, cardiac, and nerve) that are rarely observable with GelMA. Here we systematically review these recent efforts in nanomaterials-combined GelMA hydrogels that are considered as next-generation multifunctional platforms for tissue therapeutics. The approaches used in GelMA can also apply to other existing polymeric hydrogel systems.Amal George KurianRajendra K. SinghKapil D. PatelJung-Hwan LeeHae-Won KimKeAi Communications Co., Ltd.articleGelMA hydrogelNanomaterialsMultifunctionalTherapeuticsTissue repairMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 267-295 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	GelMA hydrogel Nanomaterials Multifunctional Therapeutics Tissue repair Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	GelMA hydrogel Nanomaterials Multifunctional Therapeutics Tissue repair Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Amal George Kurian Rajendra K. Singh Kapil D. Patel Jung-Hwan Lee Hae-Won Kim Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
description	Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules and cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-based hydrogels have been devoted to combining them with bioactive and functional nanomaterials, aiming to provide enhanced physicochemical and biological properties to GelMA. The benefits of this approach are multiple: i) reinforcing mechanical properties, ii) modulating viscoelastic property to allow 3D printability of bio-inks, iii) rendering electrical/magnetic property to produce electro-/magneto-active hydrogels for the repair of specific tissues (e.g., muscle, nerve), iv) providing stimuli-responsiveness to actively deliver therapeutic molecules, and v) endowing therapeutic capacity in tissue repair process (e.g., antioxidant effects). The nanomaterial-combined GelMA systems have shown significantly enhanced and extraordinary behaviors in various tissues (bone, skin, cardiac, and nerve) that are rarely observable with GelMA. Here we systematically review these recent efforts in nanomaterials-combined GelMA hydrogels that are considered as next-generation multifunctional platforms for tissue therapeutics. The approaches used in GelMA can also apply to other existing polymeric hydrogel systems.
format	article
author	Amal George Kurian Rajendra K. Singh Kapil D. Patel Jung-Hwan Lee Hae-Won Kim
author_facet	Amal George Kurian Rajendra K. Singh Kapil D. Patel Jung-Hwan Lee Hae-Won Kim
author_sort	Amal George Kurian
title	Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
title_short	Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
title_full	Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
title_fullStr	Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
title_full_unstemmed	Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
title_sort	multifunctional gelma platforms with nanomaterials for advanced tissue therapeutics
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/81bf0b5e6b234dc6a30d7fa76a092361
work_keys_str_mv	AT amalgeorgekurian multifunctionalgelmaplatformswithnanomaterialsforadvancedtissuetherapeutics AT rajendraksingh multifunctionalgelmaplatformswithnanomaterialsforadvancedtissuetherapeutics AT kapildpatel multifunctionalgelmaplatformswithnanomaterialsforadvancedtissuetherapeutics AT junghwanlee multifunctionalgelmaplatformswithnanomaterialsforadvancedtissuetherapeutics AT haewonkim multifunctionalgelmaplatformswithnanomaterialsforadvancedtissuetherapeutics
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Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

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