TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut
Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T...
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Nature Portfolio
2017
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oai:doaj.org-article:81c11da70637480eb4d002bc8644c76b2021-12-02T15:38:50ZTRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut10.1038/s41467-017-01960-z2041-1723https://doaj.org/article/81c11da70637480eb4d002bc8644c76b2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01960-zhttps://doaj.org/toc/2041-1723Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cellsAndrea RomagnaniValentina VettoreTanja Rezzonico-JostSarah HampeElsa RottoliWiebke NadolniMichela PerottiMelanie A. MeierConstanze HermannsSheila GeigerGunther WennemuthCamilla RecordatiMasayuki MatsushitaSusanne MuehlichMichele ProiettiVladimir ChubanovThomas GudermannFabio GrassiSusanna ZierlerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Andrea Romagnani Valentina Vettore Tanja Rezzonico-Jost Sarah Hampe Elsa Rottoli Wiebke Nadolni Michela Perotti Melanie A. Meier Constanze Hermanns Sheila Geiger Gunther Wennemuth Camilla Recordati Masayuki Matsushita Susanne Muehlich Michele Proietti Vladimir Chubanov Thomas Gudermann Fabio Grassi Susanna Zierler TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut |
| description |
Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells |
| format |
article |
| author |
Andrea Romagnani Valentina Vettore Tanja Rezzonico-Jost Sarah Hampe Elsa Rottoli Wiebke Nadolni Michela Perotti Melanie A. Meier Constanze Hermanns Sheila Geiger Gunther Wennemuth Camilla Recordati Masayuki Matsushita Susanne Muehlich Michele Proietti Vladimir Chubanov Thomas Gudermann Fabio Grassi Susanna Zierler |
| author_facet |
Andrea Romagnani Valentina Vettore Tanja Rezzonico-Jost Sarah Hampe Elsa Rottoli Wiebke Nadolni Michela Perotti Melanie A. Meier Constanze Hermanns Sheila Geiger Gunther Wennemuth Camilla Recordati Masayuki Matsushita Susanne Muehlich Michele Proietti Vladimir Chubanov Thomas Gudermann Fabio Grassi Susanna Zierler |
| author_sort |
Andrea Romagnani |
| title |
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut |
| title_short |
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut |
| title_full |
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut |
| title_fullStr |
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut |
| title_full_unstemmed |
TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut |
| title_sort |
trpm7 kinase activity is essential for t cell colonization and alloreactivity in the gut |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/81c11da70637480eb4d002bc8644c76b |
| work_keys_str_mv |
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1718386058584915968 |