The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer

Abstract Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity to motion. MRF has shown promise in improving the diagnosis of clinically significant prostate cancer but requires further vali...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nikita Sushentsev, Joshua D. Kaggie, Guido Buonincontri, Rolf F. Schulte, Martin J. Graves, Vincent J. Gnanapragasam, Tristan Barrett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81c721663a3f4bd69a1302e777813715
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:81c721663a3f4bd69a1302e777813715
record_format	dspace
spelling	oai:doaj.org-article:81c721663a3f4bd69a1302e7778137152021-12-02T12:33:53ZThe effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer10.1038/s41598-020-77331-42045-2322https://doaj.org/article/81c721663a3f4bd69a1302e7778137152020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77331-4https://doaj.org/toc/2045-2322Abstract Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity to motion. MRF has shown promise in improving the diagnosis of clinically significant prostate cancer but requires further validation as part of a prostate multiparametric (mp) MRI protocol. mpMRI protocol mandates the inclusion of dynamic contrast enhanced (DCE) imaging, known for its significant T1 shortening effect. MRF could be used to measure both pre- and post-contrast T1 values, but its utility must be assessed. In this proof-of-concept study, we sought to evaluate the variation in MRF T1 measurements post gadolinium-based contrast agent (GBCA) injection and the utility of such T1 measurements to differentiate peripheral and transition zone tumours from normal prostatic tissue. We found that the T1 variation in all tissues increased considerably post-GBCA following the expected significant T1 shortening effect, compromising the ability of MRF T1 to identify transition zone lesions. We, therefore, recommend performing MRF T1 prior to DCE imaging to maintain its benefit for improving detection of both peripheral and transition zone lesions while reducing additional scanning time. Demonstrating the effect of GBCA on MRF T1 relaxometry in patients also paves the way for future clinical studies investigating the added value of post-GBCA MRF in PCa, including its dynamic analysis as in DCE-MRF.Nikita SushentsevJoshua D. KaggieGuido BuonincontriRolf F. SchulteMartin J. GravesVincent J. GnanapragasamTristan BarrettNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nikita Sushentsev Joshua D. Kaggie Guido Buonincontri Rolf F. Schulte Martin J. Graves Vincent J. Gnanapragasam Tristan Barrett The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer
description	Abstract Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity to motion. MRF has shown promise in improving the diagnosis of clinically significant prostate cancer but requires further validation as part of a prostate multiparametric (mp) MRI protocol. mpMRI protocol mandates the inclusion of dynamic contrast enhanced (DCE) imaging, known for its significant T1 shortening effect. MRF could be used to measure both pre- and post-contrast T1 values, but its utility must be assessed. In this proof-of-concept study, we sought to evaluate the variation in MRF T1 measurements post gadolinium-based contrast agent (GBCA) injection and the utility of such T1 measurements to differentiate peripheral and transition zone tumours from normal prostatic tissue. We found that the T1 variation in all tissues increased considerably post-GBCA following the expected significant T1 shortening effect, compromising the ability of MRF T1 to identify transition zone lesions. We, therefore, recommend performing MRF T1 prior to DCE imaging to maintain its benefit for improving detection of both peripheral and transition zone lesions while reducing additional scanning time. Demonstrating the effect of GBCA on MRF T1 relaxometry in patients also paves the way for future clinical studies investigating the added value of post-GBCA MRF in PCa, including its dynamic analysis as in DCE-MRF.
format	article
author	Nikita Sushentsev Joshua D. Kaggie Guido Buonincontri Rolf F. Schulte Martin J. Graves Vincent J. Gnanapragasam Tristan Barrett
author_facet	Nikita Sushentsev Joshua D. Kaggie Guido Buonincontri Rolf F. Schulte Martin J. Graves Vincent J. Gnanapragasam Tristan Barrett
author_sort	Nikita Sushentsev
title	The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer
title_short	The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer
title_full	The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer
title_fullStr	The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer
title_full_unstemmed	The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer
title_sort	effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based t1 relaxometry in patients with prostate cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/81c721663a3f4bd69a1302e777813715
work_keys_str_mv	AT nikitasushentsev theeffectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT joshuadkaggie theeffectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT guidobuonincontri theeffectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT rolffschulte theeffectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT martinjgraves theeffectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT vincentjgnanapragasam theeffectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT tristanbarrett theeffectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT nikitasushentsev effectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT joshuadkaggie effectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT guidobuonincontri effectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT rolffschulte effectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT martinjgraves effectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT vincentjgnanapragasam effectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer AT tristanbarrett effectofgadoliniumbasedcontrastagentadministrationonmagneticresonancefingerprintingbasedt1relaxometryinpatientswithprostatecancer
_version_	1718393869215727616

The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer

Ejemplares similares