Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic

Red blood cells (RBCs) have unique properties that have been exploited for therapeutic uses. Here the authors engineer RBCs to co-express tumor associated antigens on MHC I, 4-1BBL and IL-12, generating artificial antigen presenting cells that can induce antigen-specific T cell responses and antitum...

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Autores principales:	Xuqing Zhang, Mengyao Luo, Shamael R. Dastagir, Mellissa Nixon, Annie Khamhoung, Andrea Schmidt, Albert Lee, Naren Subbiah, Douglas C. McLaughlin, Christopher L. Moore, Mary Gribble, Nicholas Bayhi, Viral Amin, Ryan Pepi, Sneha Pawar, Timothy J. Lyford, Vikram Soman, Jennifer Mellen, Christopher L. Carpenter, Laurence A. Turka, Thomas J. Wickham, Tiffany F. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81c7237bdaba401f8b24431f73e5d95a
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spelling	oai:doaj.org-article:81c7237bdaba401f8b24431f73e5d95a2021-12-02T14:35:38ZEngineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic10.1038/s41467-021-22898-32041-1723https://doaj.org/article/81c7237bdaba401f8b24431f73e5d95a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22898-3https://doaj.org/toc/2041-1723Red blood cells (RBCs) have unique properties that have been exploited for therapeutic uses. Here the authors engineer RBCs to co-express tumor associated antigens on MHC I, 4-1BBL and IL-12, generating artificial antigen presenting cells that can induce antigen-specific T cell responses and antitumor immune responses in preclinical models.Xuqing ZhangMengyao LuoShamael R. DastagirMellissa NixonAnnie KhamhoungAndrea SchmidtAlbert LeeNaren SubbiahDouglas C. McLaughlinChristopher L. MooreMary GribbleNicholas BayhiViral AminRyan PepiSneha PawarTimothy J. LyfordVikram SomanJennifer MellenChristopher L. CarpenterLaurence A. TurkaThomas J. WickhamTiffany F. ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuqing Zhang Mengyao Luo Shamael R. Dastagir Mellissa Nixon Annie Khamhoung Andrea Schmidt Albert Lee Naren Subbiah Douglas C. McLaughlin Christopher L. Moore Mary Gribble Nicholas Bayhi Viral Amin Ryan Pepi Sneha Pawar Timothy J. Lyford Vikram Soman Jennifer Mellen Christopher L. Carpenter Laurence A. Turka Thomas J. Wickham Tiffany F. Chen Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
description	Red blood cells (RBCs) have unique properties that have been exploited for therapeutic uses. Here the authors engineer RBCs to co-express tumor associated antigens on MHC I, 4-1BBL and IL-12, generating artificial antigen presenting cells that can induce antigen-specific T cell responses and antitumor immune responses in preclinical models.
format	article
author	Xuqing Zhang Mengyao Luo Shamael R. Dastagir Mellissa Nixon Annie Khamhoung Andrea Schmidt Albert Lee Naren Subbiah Douglas C. McLaughlin Christopher L. Moore Mary Gribble Nicholas Bayhi Viral Amin Ryan Pepi Sneha Pawar Timothy J. Lyford Vikram Soman Jennifer Mellen Christopher L. Carpenter Laurence A. Turka Thomas J. Wickham Tiffany F. Chen
author_facet	Xuqing Zhang Mengyao Luo Shamael R. Dastagir Mellissa Nixon Annie Khamhoung Andrea Schmidt Albert Lee Naren Subbiah Douglas C. McLaughlin Christopher L. Moore Mary Gribble Nicholas Bayhi Viral Amin Ryan Pepi Sneha Pawar Timothy J. Lyford Vikram Soman Jennifer Mellen Christopher L. Carpenter Laurence A. Turka Thomas J. Wickham Tiffany F. Chen
author_sort	Xuqing Zhang
title	Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
title_short	Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
title_full	Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
title_fullStr	Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
title_full_unstemmed	Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
title_sort	engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81c7237bdaba401f8b24431f73e5d95a
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Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic

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