Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcripti...

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Autores principales: Amit Grover, Alejandra Sanjuan-Pla, Supat Thongjuea, Joana Carrelha, Alice Giustacchini, Adriana Gambardella, Iain Macaulay, Elena Mancini, Tiago C. Luis, Adam Mead, Sten Eirik W. Jacobsen, Claus Nerlov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/81c978c8b4c243cab74583942727f9f7
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Sumario:With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.

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