Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcripti...

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Autores principales:	Amit Grover, Alejandra Sanjuan-Pla, Supat Thongjuea, Joana Carrelha, Alice Giustacchini, Adriana Gambardella, Iain Macaulay, Elena Mancini, Tiago C. Luis, Adam Mead, Sten Eirik W. Jacobsen, Claus Nerlov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81c978c8b4c243cab74583942727f9f7
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spelling	oai:doaj.org-article:81c978c8b4c243cab74583942727f9f72021-12-02T14:38:54ZSingle-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells10.1038/ncomms110752041-1723https://doaj.org/article/81c978c8b4c243cab74583942727f9f72016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11075https://doaj.org/toc/2041-1723With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.Amit GroverAlejandra Sanjuan-PlaSupat ThongjueaJoana CarrelhaAlice GiustacchiniAdriana GambardellaIain MacaulayElena ManciniTiago C. LuisAdam MeadSten Eirik W. JacobsenClaus NerlovNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amit Grover Alejandra Sanjuan-Pla Supat Thongjuea Joana Carrelha Alice Giustacchini Adriana Gambardella Iain Macaulay Elena Mancini Tiago C. Luis Adam Mead Sten Eirik W. Jacobsen Claus Nerlov Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
description	With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.
format	article
author	Amit Grover Alejandra Sanjuan-Pla Supat Thongjuea Joana Carrelha Alice Giustacchini Adriana Gambardella Iain Macaulay Elena Mancini Tiago C. Luis Adam Mead Sten Eirik W. Jacobsen Claus Nerlov
author_facet	Amit Grover Alejandra Sanjuan-Pla Supat Thongjuea Joana Carrelha Alice Giustacchini Adriana Gambardella Iain Macaulay Elena Mancini Tiago C. Luis Adam Mead Sten Eirik W. Jacobsen Claus Nerlov
author_sort	Amit Grover
title	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_short	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_full	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_fullStr	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_full_unstemmed	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_sort	single-cell rna sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/81c978c8b4c243cab74583942727f9f7
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Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

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