Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.

Damage in the nervous system induces a stereotypical response that is mediated by glial cells. Here, we use the eye disc of Drosophila melanogaster as a model to explore the mechanisms involved in promoting glial cell response after neuronal cell death induction. We demonstrate that these cells rapi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sergio B Velarde, Alvaro Quevedo, Carlos Estella, Antonio Baonza
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/81c9d7ebd4a147bca1b21903be1f5a22
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:81c9d7ebd4a147bca1b21903be1f5a22
record_format	dspace
spelling	oai:doaj.org-article:81c9d7ebd4a147bca1b21903be1f5a222021-12-02T19:54:40ZDpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.1544-91731545-788510.1371/journal.pbio.3001367https://doaj.org/article/81c9d7ebd4a147bca1b21903be1f5a222021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001367https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Damage in the nervous system induces a stereotypical response that is mediated by glial cells. Here, we use the eye disc of Drosophila melanogaster as a model to explore the mechanisms involved in promoting glial cell response after neuronal cell death induction. We demonstrate that these cells rapidly respond to neuronal apoptosis by increasing in number and undergoing morphological changes, which will ultimately grant them phagocytic abilities. We found that this glial response is controlled by the activity of Decapentaplegic (Dpp) and Hedgehog (Hh) signalling pathways. These pathways are activated after cell death induction, and their functions are necessary to induce glial cell proliferation and migration to the eye discs. The latter of these 2 processes depend on the function of the c-Jun N-terminal kinase (JNK) pathway, which is activated by Dpp signalling. We also present evidence that a similar mechanism controls glial response upon apoptosis induction in the leg discs, suggesting that our results uncover a mechanism that might be involved in controlling glial cells response to neuronal cell death in different regions of the peripheral nervous system (PNS).Sergio B VelardeAlvaro QuevedoCarlos EstellaAntonio BaonzaPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 8, p e3001367 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sergio B Velarde Alvaro Quevedo Carlos Estella Antonio Baonza Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
description	Damage in the nervous system induces a stereotypical response that is mediated by glial cells. Here, we use the eye disc of Drosophila melanogaster as a model to explore the mechanisms involved in promoting glial cell response after neuronal cell death induction. We demonstrate that these cells rapidly respond to neuronal apoptosis by increasing in number and undergoing morphological changes, which will ultimately grant them phagocytic abilities. We found that this glial response is controlled by the activity of Decapentaplegic (Dpp) and Hedgehog (Hh) signalling pathways. These pathways are activated after cell death induction, and their functions are necessary to induce glial cell proliferation and migration to the eye discs. The latter of these 2 processes depend on the function of the c-Jun N-terminal kinase (JNK) pathway, which is activated by Dpp signalling. We also present evidence that a similar mechanism controls glial response upon apoptosis induction in the leg discs, suggesting that our results uncover a mechanism that might be involved in controlling glial cells response to neuronal cell death in different regions of the peripheral nervous system (PNS).
format	article
author	Sergio B Velarde Alvaro Quevedo Carlos Estella Antonio Baonza
author_facet	Sergio B Velarde Alvaro Quevedo Carlos Estella Antonio Baonza
author_sort	Sergio B Velarde
title	Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
title_short	Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
title_full	Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
title_fullStr	Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
title_full_unstemmed	Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
title_sort	dpp and hedgehog promote the glial response to neuronal apoptosis in the developing drosophila visual system.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/81c9d7ebd4a147bca1b21903be1f5a22
work_keys_str_mv	AT sergiobvelarde dppandhedgehogpromotetheglialresponsetoneuronalapoptosisinthedevelopingdrosophilavisualsystem AT alvaroquevedo dppandhedgehogpromotetheglialresponsetoneuronalapoptosisinthedevelopingdrosophilavisualsystem AT carlosestella dppandhedgehogpromotetheglialresponsetoneuronalapoptosisinthedevelopingdrosophilavisualsystem AT antoniobaonza dppandhedgehogpromotetheglialresponsetoneuronalapoptosisinthedevelopingdrosophilavisualsystem
_version_	1718375909325537280

Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.

Ejemplares similares