Enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.

The aim of this study was to assess the relationship between the enhancement patterns and clinicopathological features of gastric cancer using intravenous contrast-enhanced ultrasonography (CEUS). In this Ethics Committee-approved prospective study, five hundred fifty two patients with gastric cance...

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Autores principales:	Fang Wei, Pintong Huang, Shiyan Li, Jian Chen, Ying Zhang, Yurong Hong, Shumei Wei, David Cosgrove
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81cf5b416cee4950b52e2135251d2a89
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spelling	oai:doaj.org-article:81cf5b416cee4950b52e2135251d2a892021-11-18T08:56:32ZEnhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.1932-620310.1371/journal.pone.0073050https://doaj.org/article/81cf5b416cee4950b52e2135251d2a892013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24039857/?tool=EBIhttps://doaj.org/toc/1932-6203The aim of this study was to assess the relationship between the enhancement patterns and clinicopathological features of gastric cancer using intravenous contrast-enhanced ultrasonography (CEUS). In this Ethics Committee-approved prospective study, five hundred fifty two patients with gastric cancer who gave informed consent were examined preoperatively with CEUS. The enhancement pattern of each tumor was analyzed visually. Gross and histopathological findings on the postoperative specimens were compared with the preoperative CEUS findings. The most common CEUS pattern in differentiated gastric cancer was homogeneous enhancement, whereas heterogeneous enhancement was the most common pattern in undifferentiated gastric cancer. The proportion of heterogeneous enhancement was significantly different between the two histological subtypes (Chi- square = 146.735, P<0.001). The sensitivity and specificity of early heterogeneous enhancement on CEUS in diagnosing undifferentiated gastric cancer were 78.84% and 72.59% respectively. Gastric cancers with heterogeneous enhancement were more often Borrmann III and IV macroscopic types than those with homogeneous enhancement (66.56% vs. 30.80%, P<0.001), more commonly T3 and T4 depth of invasion than those with homogeneous enhancement (71.52% vs. 59.60%, P<0.05), more often showed lymphatic invasion than those with homogeneous enhancement (84.44% vs. 76.40%, P<0.05), and were less likely to receive curative gastrectomy than those with homogeneous enhancement (74.83% vs. 86.40%, P<0.005). The intra- and inter-observer reproducibility were both almost perfect for assessing enhancement patterns, with Kappa values of 0.916 (P<0.001) for intra-observer and 0.842 (P<0.001) for inter-observer reproducibility. CEUS provided detailed information about tumor vascularity and contrast enhancement patterns in gastric cancer. CEUS is promising as a new and useful method to predict the histological type of gastric cancer.Fang WeiPintong HuangShiyan LiJian ChenYing ZhangYurong HongShumei WeiDavid CosgrovePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73050 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fang Wei Pintong Huang Shiyan Li Jian Chen Ying Zhang Yurong Hong Shumei Wei David Cosgrove Enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.
description	The aim of this study was to assess the relationship between the enhancement patterns and clinicopathological features of gastric cancer using intravenous contrast-enhanced ultrasonography (CEUS). In this Ethics Committee-approved prospective study, five hundred fifty two patients with gastric cancer who gave informed consent were examined preoperatively with CEUS. The enhancement pattern of each tumor was analyzed visually. Gross and histopathological findings on the postoperative specimens were compared with the preoperative CEUS findings. The most common CEUS pattern in differentiated gastric cancer was homogeneous enhancement, whereas heterogeneous enhancement was the most common pattern in undifferentiated gastric cancer. The proportion of heterogeneous enhancement was significantly different between the two histological subtypes (Chi- square = 146.735, P<0.001). The sensitivity and specificity of early heterogeneous enhancement on CEUS in diagnosing undifferentiated gastric cancer were 78.84% and 72.59% respectively. Gastric cancers with heterogeneous enhancement were more often Borrmann III and IV macroscopic types than those with homogeneous enhancement (66.56% vs. 30.80%, P<0.001), more commonly T3 and T4 depth of invasion than those with homogeneous enhancement (71.52% vs. 59.60%, P<0.05), more often showed lymphatic invasion than those with homogeneous enhancement (84.44% vs. 76.40%, P<0.05), and were less likely to receive curative gastrectomy than those with homogeneous enhancement (74.83% vs. 86.40%, P<0.005). The intra- and inter-observer reproducibility were both almost perfect for assessing enhancement patterns, with Kappa values of 0.916 (P<0.001) for intra-observer and 0.842 (P<0.001) for inter-observer reproducibility. CEUS provided detailed information about tumor vascularity and contrast enhancement patterns in gastric cancer. CEUS is promising as a new and useful method to predict the histological type of gastric cancer.
format	article
author	Fang Wei Pintong Huang Shiyan Li Jian Chen Ying Zhang Yurong Hong Shumei Wei David Cosgrove
author_facet	Fang Wei Pintong Huang Shiyan Li Jian Chen Ying Zhang Yurong Hong Shumei Wei David Cosgrove
author_sort	Fang Wei
title	Enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.
title_short	Enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.
title_full	Enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.
title_fullStr	Enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.
title_full_unstemmed	Enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.
title_sort	enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/81cf5b416cee4950b52e2135251d2a89
work_keys_str_mv	AT fangwei enhancementpatternsofgastriccarcinomaoncontrastenhancedultrasonographyrelationshipwithclinicopathologicalfeatures AT pintonghuang enhancementpatternsofgastriccarcinomaoncontrastenhancedultrasonographyrelationshipwithclinicopathologicalfeatures AT shiyanli enhancementpatternsofgastriccarcinomaoncontrastenhancedultrasonographyrelationshipwithclinicopathologicalfeatures AT jianchen enhancementpatternsofgastriccarcinomaoncontrastenhancedultrasonographyrelationshipwithclinicopathologicalfeatures AT yingzhang enhancementpatternsofgastriccarcinomaoncontrastenhancedultrasonographyrelationshipwithclinicopathologicalfeatures AT yuronghong enhancementpatternsofgastriccarcinomaoncontrastenhancedultrasonographyrelationshipwithclinicopathologicalfeatures AT shumeiwei enhancementpatternsofgastriccarcinomaoncontrastenhancedultrasonographyrelationshipwithclinicopathologicalfeatures AT davidcosgrove enhancementpatternsofgastriccarcinomaoncontrastenhancedultrasonographyrelationshipwithclinicopathologicalfeatures
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Enhancement patterns of gastric carcinoma on contrast-enhanced ultrasonography: relationship with clinicopathological features.

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