Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil

Abstract The prevalence of anti-hepatitis E virus (HEV) antibodies has a high heterogeneity worldwide. South American data are still scarce. The aim of this study was to evaluate the prevalence of HEV in populations at risk in comparison to blood donors (BD). A cross-sectional study was carried out...

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Autores principales:	Marisa Boff Costa, Michele Soares Gomes Gouvêa, Samira Chuffi, Gustavo Hirata Dellavia, Felipe Ornel, Lísia Von Diemen, Félix Kessler, João Renato Rebello Pinho, Mário Reis Álvares-da-Silva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/81d15aa0849448b8af7042e3164c0e87
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spelling	oai:doaj.org-article:81d15aa0849448b8af7042e3164c0e872021-12-02T16:30:37ZSeroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil10.1038/s41598-021-85365-52045-2322https://doaj.org/article/81d15aa0849448b8af7042e3164c0e872021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85365-5https://doaj.org/toc/2045-2322Abstract The prevalence of anti-hepatitis E virus (HEV) antibodies has a high heterogeneity worldwide. South American data are still scarce. The aim of this study was to evaluate the prevalence of HEV in populations at risk in comparison to blood donors (BD). A cross-sectional study was carried out in adults of different risk populations including crack users (CK), residents in a low income area (LIA), cirrhotic (CIR) and liver transplant patients (LT) compared with BD. The WANTAI HEV ELISA test was used and real-time PCR (in-house for screening and ALTONA as confirmatory test) for HEV RNA screening. A total of 400 participants were included. Anti-HEV IgG was positive in 19.5% of the total sample, reaching the highest rate in the CIR group, 22.5%, followed by CK, LT, and LIA (20%, 18.7%, and 17.5%, respectively). The prevalence found in BD individuals was of 18.7% (p = NS). Anti-HEV IgM was positive in only 1.5% of the sample (6/400). No blood or stools samples were positive for HEV RNA. The seroprevalence reported is among the highest rates ever found in Brazil. Considering the intense diagnostic investigation, data show that HEV circulation is more common that might be expected in our country.Marisa Boff CostaMichele Soares Gomes GouvêaSamira ChuffiGustavo Hirata DellaviaFelipe OrnelLísia Von DiemenFélix KesslerJoão Renato Rebello PinhoMário Reis Álvares-da-SilvaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marisa Boff Costa Michele Soares Gomes Gouvêa Samira Chuffi Gustavo Hirata Dellavia Felipe Ornel Lísia Von Diemen Félix Kessler João Renato Rebello Pinho Mário Reis Álvares-da-Silva Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil
description	Abstract The prevalence of anti-hepatitis E virus (HEV) antibodies has a high heterogeneity worldwide. South American data are still scarce. The aim of this study was to evaluate the prevalence of HEV in populations at risk in comparison to blood donors (BD). A cross-sectional study was carried out in adults of different risk populations including crack users (CK), residents in a low income area (LIA), cirrhotic (CIR) and liver transplant patients (LT) compared with BD. The WANTAI HEV ELISA test was used and real-time PCR (in-house for screening and ALTONA as confirmatory test) for HEV RNA screening. A total of 400 participants were included. Anti-HEV IgG was positive in 19.5% of the total sample, reaching the highest rate in the CIR group, 22.5%, followed by CK, LT, and LIA (20%, 18.7%, and 17.5%, respectively). The prevalence found in BD individuals was of 18.7% (p = NS). Anti-HEV IgM was positive in only 1.5% of the sample (6/400). No blood or stools samples were positive for HEV RNA. The seroprevalence reported is among the highest rates ever found in Brazil. Considering the intense diagnostic investigation, data show that HEV circulation is more common that might be expected in our country.
format	article
author	Marisa Boff Costa Michele Soares Gomes Gouvêa Samira Chuffi Gustavo Hirata Dellavia Felipe Ornel Lísia Von Diemen Félix Kessler João Renato Rebello Pinho Mário Reis Álvares-da-Silva
author_facet	Marisa Boff Costa Michele Soares Gomes Gouvêa Samira Chuffi Gustavo Hirata Dellavia Felipe Ornel Lísia Von Diemen Félix Kessler João Renato Rebello Pinho Mário Reis Álvares-da-Silva
author_sort	Marisa Boff Costa
title	Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil
title_short	Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil
title_full	Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil
title_fullStr	Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil
title_full_unstemmed	Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil
title_sort	seroprevalence of hepatitis e virus in risk populations and blood donors in a referral hospital in the south of brazil
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81d15aa0849448b8af7042e3164c0e87
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Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil

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