Chronic sleep disturbance and neural injury: links to neurodegenerative disease
Sabra M Abbott,1 Aleksandar Videnovic21Department of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL, USA; 2Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Abstract: Sleep–wake disruption is frequently observed and often on...
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Dove Medical Press
2016
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oai:doaj.org-article:81d19345f9ce423f95e232f44d5305b22021-12-02T05:03:25ZChronic sleep disturbance and neural injury: links to neurodegenerative disease1179-1608https://doaj.org/article/81d19345f9ce423f95e232f44d5305b22016-01-01T00:00:00Zhttps://www.dovepress.com/chronic-sleep-disturbance-and-neural-injury-links-to-neurodegenerative-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Sabra M Abbott,1 Aleksandar Videnovic21Department of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL, USA; 2Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Abstract: Sleep–wake disruption is frequently observed and often one of the earliest reported symptoms of many neurodegenerative disorders. This provides insight into the underlying pathophysiology of these disorders, as sleep–wake abnormalities are often accompanied by neurodegenerative or neurotransmitter changes. However, in addition to being a symptom of the underlying neurodegenerative condition, there is also emerging evidence that sleep disturbance itself may contribute to the development and facilitate the progression of several of these disorders. Due to its impact both as an early symptom and as a potential factor contributing to ongoing neurodegeneration, the sleep–wake cycle is an ideal target for further study for potential interventions not only to lessen the burden of these diseases but also to slow their progression. In this review, we will highlight the sleep phenotypes associated with some of the major neurodegenerative disorders, focusing on the circadian disruption associated with Alzheimer’s disease, the rapid eye movement behavior disorder and sleep fragmentation associated with Parkinson’s disease, and the insomnia and circadian dysregulation associated with Huntington’s disease. Keywords: sleep, neurodegeneration, Alzheimer's disease, Parkinson's disease, Huntington's diseaseAbbott SMVidenovic ADove Medical PressarticleSleepneurodegenerationAlzheimer’s diseaseParkinson’s diseaseHuntington’s diseasePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2016, Iss Issue 1, Pp 55-61 (2016) |
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DOAJ |
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DOAJ |
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EN |
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Sleep neurodegeneration Alzheimer’s disease Parkinson’s disease Huntington’s disease Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 |
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Sleep neurodegeneration Alzheimer’s disease Parkinson’s disease Huntington’s disease Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Abbott SM Videnovic A Chronic sleep disturbance and neural injury: links to neurodegenerative disease |
| description |
Sabra M Abbott,1 Aleksandar Videnovic21Department of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL, USA; 2Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Abstract: Sleep–wake disruption is frequently observed and often one of the earliest reported symptoms of many neurodegenerative disorders. This provides insight into the underlying pathophysiology of these disorders, as sleep–wake abnormalities are often accompanied by neurodegenerative or neurotransmitter changes. However, in addition to being a symptom of the underlying neurodegenerative condition, there is also emerging evidence that sleep disturbance itself may contribute to the development and facilitate the progression of several of these disorders. Due to its impact both as an early symptom and as a potential factor contributing to ongoing neurodegeneration, the sleep–wake cycle is an ideal target for further study for potential interventions not only to lessen the burden of these diseases but also to slow their progression. In this review, we will highlight the sleep phenotypes associated with some of the major neurodegenerative disorders, focusing on the circadian disruption associated with Alzheimer’s disease, the rapid eye movement behavior disorder and sleep fragmentation associated with Parkinson’s disease, and the insomnia and circadian dysregulation associated with Huntington’s disease. Keywords: sleep, neurodegeneration, Alzheimer's disease, Parkinson's disease, Huntington's disease |
| format |
article |
| author |
Abbott SM Videnovic A |
| author_facet |
Abbott SM Videnovic A |
| author_sort |
Abbott SM |
| title |
Chronic sleep disturbance and neural injury: links to neurodegenerative disease |
| title_short |
Chronic sleep disturbance and neural injury: links to neurodegenerative disease |
| title_full |
Chronic sleep disturbance and neural injury: links to neurodegenerative disease |
| title_fullStr |
Chronic sleep disturbance and neural injury: links to neurodegenerative disease |
| title_full_unstemmed |
Chronic sleep disturbance and neural injury: links to neurodegenerative disease |
| title_sort |
chronic sleep disturbance and neural injury: links to neurodegenerative disease |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/81d19345f9ce423f95e232f44d5305b2 |
| work_keys_str_mv |
AT abbottsm chronicsleepdisturbanceandneuralinjurylinkstoneurodegenerativedisease AT videnovica chronicsleepdisturbanceandneuralinjurylinkstoneurodegenerativedisease |
| _version_ |
1718400720480239616 |