Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects
Mutations in the RNA binding protein FUS are associated with ALS. Here the authors show that in FUS knock-in mice there is a progressive increase in neuronal activity in the frontal cortex which is associated with altered synaptic gene expression.
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Nature Portfolio
2021
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oai:doaj.org-article:81d53965ba1c4f5cbe4fa11bc13113fd2021-12-02T15:53:07ZCytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects10.1038/s41467-021-23187-92041-1723https://doaj.org/article/81d53965ba1c4f5cbe4fa11bc13113fd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23187-9https://doaj.org/toc/2041-1723Mutations in the RNA binding protein FUS are associated with ALS. Here the authors show that in FUS knock-in mice there is a progressive increase in neuronal activity in the frontal cortex which is associated with altered synaptic gene expression.Jelena Scekic-ZahirovicInmaculada Sanjuan-RuizVanessa KanSalim MegatPierre De RossiStéphane DieterléRaphaelle CasselMarguerite JametPascal KesslerDiana WiesnerLaura TzeplaeffValérie DemaisSonu SahadevanKatharina M. HembachHans-Peter MullerGina PicchiarelliNibha MishraStefano AntonucciSylvie Dirrig-GroschJan KassubekVolker RascheAlbert LudolphAnne-Laurence BoutillierFrancesco RoselliMagdalini PolymenidouClotilde Lagier-TourenneSabine LiebscherLuc DupuisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Jelena Scekic-Zahirovic Inmaculada Sanjuan-Ruiz Vanessa Kan Salim Megat Pierre De Rossi Stéphane Dieterlé Raphaelle Cassel Marguerite Jamet Pascal Kessler Diana Wiesner Laura Tzeplaeff Valérie Demais Sonu Sahadevan Katharina M. Hembach Hans-Peter Muller Gina Picchiarelli Nibha Mishra Stefano Antonucci Sylvie Dirrig-Grosch Jan Kassubek Volker Rasche Albert Ludolph Anne-Laurence Boutillier Francesco Roselli Magdalini Polymenidou Clotilde Lagier-Tourenne Sabine Liebscher Luc Dupuis Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects |
| description |
Mutations in the RNA binding protein FUS are associated with ALS. Here the authors show that in FUS knock-in mice there is a progressive increase in neuronal activity in the frontal cortex which is associated with altered synaptic gene expression. |
| format |
article |
| author |
Jelena Scekic-Zahirovic Inmaculada Sanjuan-Ruiz Vanessa Kan Salim Megat Pierre De Rossi Stéphane Dieterlé Raphaelle Cassel Marguerite Jamet Pascal Kessler Diana Wiesner Laura Tzeplaeff Valérie Demais Sonu Sahadevan Katharina M. Hembach Hans-Peter Muller Gina Picchiarelli Nibha Mishra Stefano Antonucci Sylvie Dirrig-Grosch Jan Kassubek Volker Rasche Albert Ludolph Anne-Laurence Boutillier Francesco Roselli Magdalini Polymenidou Clotilde Lagier-Tourenne Sabine Liebscher Luc Dupuis |
| author_facet |
Jelena Scekic-Zahirovic Inmaculada Sanjuan-Ruiz Vanessa Kan Salim Megat Pierre De Rossi Stéphane Dieterlé Raphaelle Cassel Marguerite Jamet Pascal Kessler Diana Wiesner Laura Tzeplaeff Valérie Demais Sonu Sahadevan Katharina M. Hembach Hans-Peter Muller Gina Picchiarelli Nibha Mishra Stefano Antonucci Sylvie Dirrig-Grosch Jan Kassubek Volker Rasche Albert Ludolph Anne-Laurence Boutillier Francesco Roselli Magdalini Polymenidou Clotilde Lagier-Tourenne Sabine Liebscher Luc Dupuis |
| author_sort |
Jelena Scekic-Zahirovic |
| title |
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects |
| title_short |
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects |
| title_full |
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects |
| title_fullStr |
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects |
| title_full_unstemmed |
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects |
| title_sort |
cytoplasmic fus triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/81d53965ba1c4f5cbe4fa11bc13113fd |
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