Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and predict patient survival and response to genotoxic...

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Autores principales:	Weiguo Zhang, Jian-Hua Mao, Wei Zhu, Anshu K. Jain, Ke Liu, James B. Brown, Gary H. Karpen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81d5d64089a14736a7f1215807ef737a
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spelling	oai:doaj.org-article:81d5d64089a14736a7f1215807ef737a2021-12-02T15:34:10ZCentromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy10.1038/ncomms126192041-1723https://doaj.org/article/81d5d64089a14736a7f1215807ef737a2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12619https://doaj.org/toc/2041-1723Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and predict patient survival and response to genotoxic therapies.Weiguo ZhangJian-Hua MaoWei ZhuAnshu K. JainKe LiuJames B. BrownGary H. KarpenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weiguo Zhang Jian-Hua Mao Wei Zhu Anshu K. Jain Ke Liu James B. Brown Gary H. Karpen Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
description	Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and predict patient survival and response to genotoxic therapies.
format	article
author	Weiguo Zhang Jian-Hua Mao Wei Zhu Anshu K. Jain Ke Liu James B. Brown Gary H. Karpen
author_facet	Weiguo Zhang Jian-Hua Mao Wei Zhu Anshu K. Jain Ke Liu James B. Brown Gary H. Karpen
author_sort	Weiguo Zhang
title	Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_short	Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_full	Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_fullStr	Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_full_unstemmed	Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_sort	centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/81d5d64089a14736a7f1215807ef737a
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Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

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