Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix

Nichrous Mlalila,1 Hulda Swai,2 Lonji Kalombo,2 Askwar Hilonga3 1School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania; 2Materials Science and Manufacturing, Council for Scientific and Industrial Research, Pretoria, South...

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Autores principales:	Mlalila N, Swai H, Kalombo L, Hilonga A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/81d68a5ecc894452af8a5535c1a48e47
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spelling	oai:doaj.org-article:81d68a5ecc894452af8a5535c1a48e472021-12-02T06:28:39ZEffects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix1177-8903https://doaj.org/article/81d68a5ecc894452af8a5535c1a48e472014-12-01T00:00:00Zhttp://www.dovepress.com/effects-of-spray-drying-on-wow-multiple-emulsions-prepared-from-a-stea-peer-reviewed-article-NSAhttps://doaj.org/toc/1177-8903 Nichrous Mlalila,1 Hulda Swai,2 Lonji Kalombo,2 Askwar Hilonga3 1School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania; 2Materials Science and Manufacturing, Council for Scientific and Industrial Research, Pretoria, South Africa; 3Department of Materials Science and Engineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania Abstract: The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use. Keywords: double emulsions, nanoparticles, pump rate, spray-drying, testosteroneMlalila NSwai HKalombo LHilonga ADove Medical PressarticleMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol 2014, Iss default, Pp 105-112 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	Medical technology R855-855.5 Chemical technology TP1-1185 Mlalila N Swai H Kalombo L Hilonga A Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
description	Nichrous Mlalila,1 Hulda Swai,2 Lonji Kalombo,2 Askwar Hilonga3 1School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania; 2Materials Science and Manufacturing, Council for Scientific and Industrial Research, Pretoria, South Africa; 3Department of Materials Science and Engineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania Abstract: The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use. Keywords: double emulsions, nanoparticles, pump rate, spray-drying, testosterone
format	article
author	Mlalila N Swai H Kalombo L Hilonga A
author_facet	Mlalila N Swai H Kalombo L Hilonga A
author_sort	Mlalila N
title	Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
title_short	Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
title_full	Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
title_fullStr	Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
title_full_unstemmed	Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
title_sort	effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/81d68a5ecc894452af8a5535c1a48e47
work_keys_str_mv	AT mlalilan effectsofspraydryingonwowmultipleemulsionspreparedfromastearicacidmatrix AT swaih effectsofspraydryingonwowmultipleemulsionspreparedfromastearicacidmatrix AT kalombol effectsofspraydryingonwowmultipleemulsionspreparedfromastearicacidmatrix AT hilongaa effectsofspraydryingonwowmultipleemulsionspreparedfromastearicacidmatrix
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Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix

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