Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3

Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical experiments with NMR measurements and show that th...

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Autores principales:	Yi-Ping Chiu, Yung-Chen Sun, De-Chen Qiu, Yu-Hao Lin, Yin-Quan Chen, Jean-Cheng Kuo, Jie-rong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81d7ea511e3d4952b1fda6c54a2147cc
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spelling	oai:doaj.org-article:81d7ea511e3d4952b1fda6c54a2147cc2021-12-02T17:31:56ZLiquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-310.1038/s41467-020-15007-32041-1723https://doaj.org/article/81d7ea511e3d4952b1fda6c54a2147cc2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15007-3https://doaj.org/toc/2041-1723Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical experiments with NMR measurements and show that the galectin-3 NTD undergoes liquid-liquid phase separation (LLPS) and agglutinates other molecules through this process.Yi-Ping ChiuYung-Chen SunDe-Chen QiuYu-Hao LinYin-Quan ChenJean-Cheng KuoJie-rong HuangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi-Ping Chiu Yung-Chen Sun De-Chen Qiu Yu-Hao Lin Yin-Quan Chen Jean-Cheng Kuo Jie-rong Huang Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
description	Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical experiments with NMR measurements and show that the galectin-3 NTD undergoes liquid-liquid phase separation (LLPS) and agglutinates other molecules through this process.
format	article
author	Yi-Ping Chiu Yung-Chen Sun De-Chen Qiu Yu-Hao Lin Yin-Quan Chen Jean-Cheng Kuo Jie-rong Huang
author_facet	Yi-Ping Chiu Yung-Chen Sun De-Chen Qiu Yu-Hao Lin Yin-Quan Chen Jean-Cheng Kuo Jie-rong Huang
author_sort	Yi-Ping Chiu
title	Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
title_short	Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
title_full	Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
title_fullStr	Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
title_full_unstemmed	Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
title_sort	liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/81d7ea511e3d4952b1fda6c54a2147cc
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Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3

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