Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis

Noor Buzaboon, Sfoug Alshammary Department of Molecular Medicine, College of Medicine and Medical Sciences, Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders, Arabian Gulf University, Manama, BahrainCorrespondence: Sfoug Alshammary Email Sfougfhs@agu.edu.bhIntroduction: Osteo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Buzaboon N, Alshammary S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	adipose-derived mesenchymal stem cells (ad-msc) bone-marrow mesenchymal stem cells (bm- msc) umbilical-cord derived mesenchymal stem cells (uc-msc) knee injury and osteoarthritis outcome score (koos) lysholm knee scoring scale (lkss) magnetic resonance observation of cartilage repair tissue (mocart) mri osteoarthritis knee score (moaks) mesenchymal cell-induced chondrogenesis (mcic) international knee documentation committee (ikdc) adult human bone marrow-derived allogeneic mesenchymal stromal cells (stempeucel®) adipose-derived stromal cells (adscs) visual analog scale (vas) western ontario and mcmaster universities arthritis index (womac) microfracture (mf) intermittent and constant osteoarthritis pain (icoap) patient global assessment (pga) matrix metalloproteinases (mmps) a disinterring and metalloprotease with thrombospondin motifs (adamts) & osteonecrosis (on). Cytology QH573-671
Acceso en línea:	https://doaj.org/article/81d83ed6e7d44058be93c968901375c7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:81d83ed6e7d44058be93c968901375c7
record_format	dspace
spelling	oai:doaj.org-article:81d83ed6e7d44058be93c968901375c72021-12-02T12:53:55ZClinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis1178-6957https://doaj.org/article/81d83ed6e7d44058be93c968901375c72020-12-01T00:00:00Zhttps://www.dovepress.com/clinical-applicability-of-adult-human-mesenchymal-stem-cell-therapy-in-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Noor Buzaboon, Sfoug Alshammary Department of Molecular Medicine, College of Medicine and Medical Sciences, Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders, Arabian Gulf University, Manama, BahrainCorrespondence: Sfoug Alshammary Email Sfougfhs@agu.edu.bhIntroduction: Osteoarthritis causes a progressive deterioration to the protective cartilage between the joints leading to chronic pain and disability. This review focuses on the intrinsic potential of MSCs to stabilize and repair the cartilage tissue of the knee joint in knee osteoarthritis (KOA) patients.Methods: An online search through the PubMed database was conducted, limiting the search to the English language and human clinical trials within the past 5 years. Twenty-one clinical trials passed the inclusion criteria. Combined, those trials involved the participation of 589 patients where the progress of the treatments was monitored between a 4-month to 7-years period. The cartilage volume and defects were observed through an MRI to provide an objective assessment. While the pain and knee function were monitored using KOOS, VAS, and WOMAC scoring scales providing a subjective assessment.Results: MRI scans obtained from clinical trials demonstrate a slowed progression of cartilage degeneration and early signs of cartilage regeneration in KOA patients at the 12-month follow-up period. No major adverse effects were observed post-intervention. The overall KOOS, WOMAC, and VAS scores in patients receiving MSC treatment were reduced, suggesting subjective improvements in knee function and pain reduction when compared to patients in the placebo group.Conclusion: The use of MSC therapy is a valid form of treatment for KOA as it targets the disease itself rather than the symptoms. We found MSC therapy in KOA patients to be safe, effective, and feasible in its execution.Keywords: adipose-derived mesenchymal stem cells, AD-MSC, bone-marrow mesenchymal stem cells, BM-MSC, umbilical-cord derived mesenchymal stem cells, UC-MSCBuzaboon NAlshammary SDove Medical Pressarticleadipose-derived mesenchymal stem cells (ad-msc)bone-marrow mesenchymal stem cells (bm- msc)umbilical-cord derived mesenchymal stem cells (uc-msc)knee injury and osteoarthritis outcome score (koos)lysholm knee scoring scale (lkss)magnetic resonance observation of cartilage repair tissue (mocart)mri osteoarthritis knee score (moaks)mesenchymal cell-induced chondrogenesis (mcic)international knee documentation committee (ikdc)adult human bone marrow-derivedallogeneic mesenchymal stromal cells (stempeucel®)adipose-derived stromal cells (adscs)visual analog scale (vas)western ontario and mcmaster universities arthritis index (womac)microfracture (mf)intermittent and constant osteoarthritis pain (icoap)patient global assessment (pga)matrix metalloproteinases (mmps)a disinterring and metalloprotease with thrombospondin motifs (adamts) & osteonecrosis (on).CytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 13, Pp 117-136 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipose-derived mesenchymal stem cells (ad-msc) bone-marrow mesenchymal stem cells (bm- msc) umbilical-cord derived mesenchymal stem cells (uc-msc) knee injury and osteoarthritis outcome score (koos) lysholm knee scoring scale (lkss) magnetic resonance observation of cartilage repair tissue (mocart) mri osteoarthritis knee score (moaks) mesenchymal cell-induced chondrogenesis (mcic) international knee documentation committee (ikdc) adult human bone marrow-derived allogeneic mesenchymal stromal cells (stempeucel®) adipose-derived stromal cells (adscs) visual analog scale (vas) western ontario and mcmaster universities arthritis index (womac) microfracture (mf) intermittent and constant osteoarthritis pain (icoap) patient global assessment (pga) matrix metalloproteinases (mmps) a disinterring and metalloprotease with thrombospondin motifs (adamts) & osteonecrosis (on). Cytology QH573-671
spellingShingle	adipose-derived mesenchymal stem cells (ad-msc) bone-marrow mesenchymal stem cells (bm- msc) umbilical-cord derived mesenchymal stem cells (uc-msc) knee injury and osteoarthritis outcome score (koos) lysholm knee scoring scale (lkss) magnetic resonance observation of cartilage repair tissue (mocart) mri osteoarthritis knee score (moaks) mesenchymal cell-induced chondrogenesis (mcic) international knee documentation committee (ikdc) adult human bone marrow-derived allogeneic mesenchymal stromal cells (stempeucel®) adipose-derived stromal cells (adscs) visual analog scale (vas) western ontario and mcmaster universities arthritis index (womac) microfracture (mf) intermittent and constant osteoarthritis pain (icoap) patient global assessment (pga) matrix metalloproteinases (mmps) a disinterring and metalloprotease with thrombospondin motifs (adamts) & osteonecrosis (on). Cytology QH573-671 Buzaboon N Alshammary S Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis
description	Noor Buzaboon, Sfoug Alshammary Department of Molecular Medicine, College of Medicine and Medical Sciences, Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders, Arabian Gulf University, Manama, BahrainCorrespondence: Sfoug Alshammary Email Sfougfhs@agu.edu.bhIntroduction: Osteoarthritis causes a progressive deterioration to the protective cartilage between the joints leading to chronic pain and disability. This review focuses on the intrinsic potential of MSCs to stabilize and repair the cartilage tissue of the knee joint in knee osteoarthritis (KOA) patients.Methods: An online search through the PubMed database was conducted, limiting the search to the English language and human clinical trials within the past 5 years. Twenty-one clinical trials passed the inclusion criteria. Combined, those trials involved the participation of 589 patients where the progress of the treatments was monitored between a 4-month to 7-years period. The cartilage volume and defects were observed through an MRI to provide an objective assessment. While the pain and knee function were monitored using KOOS, VAS, and WOMAC scoring scales providing a subjective assessment.Results: MRI scans obtained from clinical trials demonstrate a slowed progression of cartilage degeneration and early signs of cartilage regeneration in KOA patients at the 12-month follow-up period. No major adverse effects were observed post-intervention. The overall KOOS, WOMAC, and VAS scores in patients receiving MSC treatment were reduced, suggesting subjective improvements in knee function and pain reduction when compared to patients in the placebo group.Conclusion: The use of MSC therapy is a valid form of treatment for KOA as it targets the disease itself rather than the symptoms. We found MSC therapy in KOA patients to be safe, effective, and feasible in its execution.Keywords: adipose-derived mesenchymal stem cells, AD-MSC, bone-marrow mesenchymal stem cells, BM-MSC, umbilical-cord derived mesenchymal stem cells, UC-MSC
format	article
author	Buzaboon N Alshammary S
author_facet	Buzaboon N Alshammary S
author_sort	Buzaboon N
title	Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis
title_short	Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis
title_full	Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis
title_fullStr	Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis
title_full_unstemmed	Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis
title_sort	clinical applicability of adult human mesenchymal stem cell therapy in the treatment of knee osteoarthritis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/81d83ed6e7d44058be93c968901375c7
work_keys_str_mv	AT buzaboonn clinicalapplicabilityofadulthumanmesenchymalstemcelltherapyinthetreatmentofkneeosteoarthritis AT alshammarys clinicalapplicabilityofadulthumanmesenchymalstemcelltherapyinthetreatmentofkneeosteoarthritis
_version_	1718393575771734016

Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis

Ejemplares similares